Publication Name	World Journal of Clinical Urology
Manuscript ID	22543
Country	United States

Received	2015-09-02 08:20
Peer-Review Started	2015-09-08 09:38
To Make the First Decision	2015-10-08 16:40
Return for Revision	2015-10-16 19:47
Revised	2015-11-24 22:04
Second Decision	2015-12-28 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-11 15:47
Articles in Press	2016-01-11 15:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-04 18:50
Publish the Manuscript Online	2016-03-18 17:49

ISSN	2219-2816 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Urology & Nephrology
Manuscript Type	Retrospective Cohort Study
Article Title	Adjuvant radiotherapy for pathologically advanced prostate cancer improves biochemical recurrence free survival compared to salvage radiotherapy
Manuscript Source	Invited Manuscript
All Author List	Robert H Blackwell, William Gange, Alexander M Kandabarow, Matthew M Harkenrider, Gopal N Gupta, Marcus L Quek and Robert C Flanigan
Funding Agency and Grant Number
Corresponding Author	Robert H Blackwell, MD, Department of Urology, Loyola University Medical Center, 2160 S, First Avenue, Building 54, Room 261, Maywood, IL 60153, United States. rblackwell@lumc.edu
Key Words	Radiotherapy; Adjuvant; Radiotherapy; Salvage therapy; Recurrence; Prostatic neoplasms
Core Tip	We evaluated the outcomes of patients who received post-prostatectomy radiotherapy (RT) who had adverse features on the pathologic specimen and an immediately undetectable prostate specific antigen (PSA) postoperatively. In this cohort of patients, those who received RT in the adjuvant therapy (e.g., while PSA remains undetectable) had an improved 5-year biochemical recurrence (BCR)-free survival of 78%, compared to 50% for patients receiving RT in the salvage setting (e.g., after the postoperative PSA has again become detectable). As such, adjuvant RT improves BCR free survival in post-prostatectomy patients with adverse pathologic features and an undetectable PSA compared to salvage RT.
Publish Date	2016-03-18 17:49
Citation	Blackwell RH, Gange W, Kandabarow AM, Harkenrider MM, Gupta GN, Quek ML, Flanigan RC. Adjuvant radiotherapy for pathologically advanced prostate cancer improves biochemical recurrence free survival compared to salvage radiotherapy. World J Clin Urol 2016; 5(1): 45-52
URL	http://www.wjgnet.com/2219-2816/full/v5/i1/45.htm
DOI	http://dx.doi.org/10.5410/wjcu.v5.i1.45

Full Article (PDF)	WJCU-5-45.pdf
Full Article (Word)	WJCU-5-45.doc
Manuscript File	22543-Review.docx
Answering Reviewers	22543-Answering reviewers.pdf
Audio Core Tip	22543-Audio core tip.mp3
Biostatistics Review Certificate	22543-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22543-Conflict-of-interest statement.pdf
Copyright License Agreement	22543-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	22543-Institutional review board statement.pdf
Peer-review Report	22543-Peer-review(s).pdf
Scientific Misconduct Check	22543-Scientific misconduct check.pdf
Scientific Editor Work List	22543-Scientific editor work list.pdf