| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jiu-Lin Song, Wei Gao, Yan Zhong, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Bo Li, Wen-Tao Wang, Hong Wu, Ming-Qing Xu, Zhe-Yu Chen, Yong-Gang Wei, Li Jiang and Jian Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Technology Support Program of Sichuan Province |
2013SZ0023 |
|
| Corresponding Author |
Lu-Nan Yan, MD, Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. yanlunan688@163.com |
| Key Words |
Liver transplantation; Minimum tacrolimus; New-onset diabetes mellitus; Immunosuppressants; Allografts failure |
| Core Tip |
New-onset diabetes mellitus (NODM) is a common and severe metabolic complication that develops after liver transplantation. It is more prominent in recipients with tacrolimus (TAC)-dominant regimens. In this study, we found that the incidence of NODM is TAC concentration (cTAC)-dependent. Using a receiver operating characteristic curve, we identified that a cutoff cTAC of 5.89 ng/mL was predictive of NODM development after 6 mo after LT. And recipients exposed to low mean cTAC developed less other TAC related complications. The strategy of maintaining cTAC below 5.89 ng/mL after 6 mo after LT is therefore safe and beneficial. |
| Publish Date |
2016-01-23 17:08 |
| Citation |
Song JL, Gao W, Zhong Y, Yan LN, Yang JY, Wen TF, Li B, Wang WT, Wu H, Xu MQ, Chen ZY, Wei YG, Jiang L, Yang J. Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation. World J Gastroenterol 2016; 22(6): 2133-2141 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i6/2133.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i6.2133 |
