Publication Name	World Journal of Nephrology
Manuscript ID	22659
Country	Canada

Received	2015-09-12 16:37
Peer-Review Started	2015-09-13 12:12
To Make the First Decision	2015-10-27 11:06
Return for Revision	2015-11-07 14:26
Revised	2015-11-23 06:11
Second Decision	2016-01-08 17:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-29 17:47
Articles in Press	2016-01-29 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 09:43
Publish the Manuscript Online	2016-03-01 14:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Major comorbid disease processes associated with increased incidence of acute kidney injury
Manuscript Source	Invited Manuscript
All Author List	Salwa Farooqi and Jeffrey G Dickhout
Funding Agency and Grant Number
Corresponding Author	Jeffrey G Dickhout, PhD, Department of Medicine, Division of Nephrology, McMaster University and St. Joseph’s Healthcare Hamilton, 50 Charlton Avenue East, Ontario L8N 4A6, Canada. jdickhou@stjosham.on.ca
Key Words	Acute kidney injury; Kidney disease; Human immunodeficiency virus; Co-morbidities; Diabetes; Cancer; Cardiac surgery; Acquired immune deficiency syndrome; Risk factors; Immune response; Cardiovascular disease
Core Tip	In order to prevent, diagnose, and prophylactically treat patients, healthcare providers must identify co-morbidities that significantly increase the likelihood of acute kidney injury (AKI). Any treatments that compromise cardiac output, renal perfusion pressure, and glomerular hemodynamics risk ischemic injury to the kidney. The innate and adaptive immune responses, which are activated by renal epithelial cell necrosis contribute to the progression of AKI. These factors have been shown to be enhanced in diabetes, cancer, cardiac surgery and human immunodeficiency virus acquired immune deficiency syndrome patients.
Publish Date	2016-03-01 14:46
Citation	Farooqi S, Dickhout JG. Major comorbid disease processes associated with increased incidence of acute kidney injury. World J Nephrol 2016; 5(2): 139-146
URL	http://www.wjgnet.com/2220-6124/full/v5/i2/139.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i2.139

Full Article (PDF)	WJN-5-139.pdf
Full Article (Word)	WJN-5-139.doc
Manuscript File	22659-Review.docx
Answering Reviewers	22659-Answering reviewers.pdf
Audio Core Tip	22659-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22659-Conflict-of-interest statement.pdf
Copyright License Agreement	22659-Copyright assignment.pdf
Peer-review Report	22659-Peer-review(s).pdf
Scientific Misconduct Check	22659-Scientific misconduct check.pdf
Scientific Editor Work List	22659-Scientific editor work list.pdf