Publication Name	World Journal of Methodology
Manuscript ID	22847
Country	United Kingdom

Received	2015-09-28 08:17
Peer-Review Started	2015-09-28 11:20
To Make the First Decision	2015-10-27 11:27
Return for Revision	2015-11-03 11:26
Revised	2015-11-17 06:57
Second Decision	2015-12-23 16:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-11 15:47
Articles in Press	2016-01-11 15:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-07 16:51
Publish the Manuscript Online	2016-03-18 09:50

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Clinical Neurology
Manuscript Type	Review
Article Title	Quo vadis motor neuron disease?
Manuscript Source	Invited Manuscript
All Author List	Rubika Balendra and Rickie Patani
Funding Agency and Grant Number	Funding Agency Grant Number A Wellcome Trust Research Training Fellowship 107196/Z/15/Z Wellcome Trust Clinician Scientist and an Anne Rowling Fellow in Regenerative Neurology
Corresponding Author	Rickie Patani, MD, PhD, Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom. rickie.patani@ucl.ac.uk
Key Words	Motor neuron disease; Amyotrophic lateral sclerosis; Neurodegeneration; Disease models
Core Tip	Motor neuron disease (MND) is a fatal neuro-degenerative disorder with no known cure. Here we discuss the organization of the motor system and the clinical presentation of MND. We detail the diagnostic criteria for amyotrophic lateral sclerosis including electrophysiological studies and potential future dia-gnostic markers of disease. We discuss the staging of disease progression in MND. We then provide an overview of disease management and end with insights into molecular pathogenesis of the disease and the use of disease models.
Publish Date	2016-03-18 09:50
Citation	Balendra R, Patani R. Quo vadis motor neuron disease? World J Methodol 2016; 6(1): 56-64
URL	http://www.wjgnet.com/2222-0682/full/v6/i1/56.htm
DOI	http://dx.doi.org/10.5662/wjm.v6.i1.56

Full Article (PDF)	WJM-6-56.pdf
Full Article (Word)	WJM-6-56.doc
Manuscript File	22847-Review.docx
Answering Reviewers	22847-Answering reviewers.pdf
Audio Core Tip	22847-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22847-Conflict-of-interest statement.pdf
Copyright License Agreement	22847-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150928063517.docx
Peer-review Report	22847-Peer-review(s).pdf
Scientific Misconduct Check	22847-Scientific misconduct check.pdf
Scientific Editor Work List	22847-Scientific editor work list.pdf