Publication Name	World Journal of Biological Chemistry
Manuscript ID	2287
Country	United States

Received	2013-02-15 17:12
Peer-Review Started	2013-02-16 14:39
To Make the First Decision	2013-03-11 14:54
Return for Revision	2013-03-22 10:56
Revised	2013-03-26 21:41
Second Decision	2013-04-10 16:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-11 05:19
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-04 12:51
Publish the Manuscript Online	2013-05-10 17:28

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Caspase-1 activation and mature interleukin-1β release are uncoupled events in monocytes
Manuscript Source	Invited Manuscript
All Author List	Amy J Galliher-Beckley, Li-Qiong Lan, Shelly Aono, Lei Wang and Jishu Shi
Funding Agency and Grant Number	Funding Agency Grant Number NIH R21 AI085416 (to Shi J) NIH NCRR P20-RR017686 (to PI: Daniel Marcus; Shi J)
Corresponding Author	Dr. Jishu Shi, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 119 Anderson Hall, Manhattan, KS 66506, United States. jshi@ksu.edu
Key Words	Caspase-1; Human defensin; Monocytes; Interleukin-1β processing and release; Inflammasome
Core Tip	Activated macrophages release large amounts of interleukin-1β (IL-1β) and macrophages deficient in caspase-1 expression have undetectable IL-1β secretion. This suggests that IL-1β release and caspase-1 activation are closely related events. We found that human α-defensin 5 (HD-5) inhibited the release of IL-1β, but not the processing of pro-IL-1β to IL-1β in lipopolysaccharide-activated monocytes stimulated with Adenosine triphosphate or nigericin. Different from IL-1β processing and release, the activation and release of caspase-1 from stimulated monocytes was not blocked by HD-5. These data suggest that caspase-1 activation/processing of pro-IL-1β by caspase-1 and the release of mature IL-1β from human monocytes are distinct and separable events.
Publish Date	2013-05-10 17:28
Citation	Galliher-Beckley AJ, Lan LQ, Aono S, Wang L, Shi J. Caspase-1 activation and mature interleukin-1β release are uncoupled events in monocytes. World J Biol Chem 2013; 4(2): 30-34
URL	http://www.wjgnet.com/1949-8454/full/v4/i2/30.htm
DOI	http://dx.doi.org/10.4331/wjbc.v4.i2.30

Full Article (PDF)	WJBC-4-30.pdf
Manuscript File	2287-Review.docx
Answering Reviewers	2287-Answering reviewers.pdf
Copyright License Agreement	2287-Copyright assignment.pdf
Peer-review Report	2287-Peer reviews.pdf
Scientific Editor Work List	2287-Scientific editor work list.doc