Publication Name	World Journal of Transplantation
Manuscript ID	22906
Country	United States

Received	2015-10-01 12:47
Peer-Review Started	2015-10-09 08:57
To Make the First Decision	2015-10-27 11:31
Return for Revision	2015-11-04 17:07
Revised	2015-12-01 05:13
Second Decision	2015-12-28 14:10
Accepted by Journal Editor-in-Chief	2015-12-28 22:04
Accepted by Executive Editor-in-Chief	2016-01-11 15:52
Articles in Press	2016-01-11 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-03 20:43
Publish the Manuscript Online	2016-03-18 14:28

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering
Manuscript Source	Invited Manuscript
All Author List	Ali Shirafkan, Mauro Montalbano, Joshua McGuire, Cristiana Rastellini and Luca Cicalese
Funding Agency and Grant Number
Corresponding Author	Luca Cicalese, MD, FACS, Professor, Texas Transplant Center, Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, United States. lucicale@utmb.edu
Key Words	Bioengineered intestine; Tissue engineered; Scaffolds; Organoids; Stem cells; Intestinal elongation techniques
Core Tip	Several methods were used to elongate the short and insufficient segment of intestine in patients suffering short bowel syndrome. These methods in-clude transplantation of an intestinal graft, intestinal elongation, and techniques to create a bioengineered segment of intestine. Innovations in using stem cells, organoid units of intestine and bio-scaffolds allow the modern medicine to engineer segments of functional intestinal tissue in animal models. However, to reach the goal of implanting a fully functional bioengineered intestine in human improvements are still required. This article will review various methods to approach this condition from surgical techniques to elongate the intestine to the application of stem cells and bio scaffolds for creating three dimensional intestinal structure.
Publish Date	2016-03-18 14:28
Citation	Shirafkan A, Montalbano M, McGuire J, Rastellini C, Cicalese L. New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering. World J Transplant 2016; 6(1): 1-9
URL	http://www.wjgnet.com/2220-3230/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i1.1

Full Article (PDF)	WJT-6-1.pdf
Full Article (Word)	WJT-6-1.doc
Manuscript File	22906-Review.docx
Answering Reviewers	22906-Answering reviewers.pdf
Audio Core Tip	22906-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22906-Conflict-of-interest statement.pdf
Copyright License Agreement	22906-Copyright assignment.pdf
Peer-review Report	22906-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22906-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22906-Scientific misconduct check.pdf
Scientific Editor Work List	22906-Scientific editor work list.pdf