Publication Name	World Journal of Gastroenterology
Manuscript ID	23014
Country	United States

Received	2015-10-13 16:47
Peer-Review Started	2015-10-14 08:07
To Make the First Decision	2015-11-13 09:32
Return for Revision	2015-11-13 15:52
Revised	2015-11-18 01:52
Second Decision	2015-11-26 16:22
Accepted by Journal Editor-in-Chief	2015-11-29 02:14
Accepted by Company Editor-in-Chief	2015-12-08 16:45
Articles in Press	2015-12-08 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-29 16:26
Publish the Manuscript Online	2016-03-02 13:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Calcium-sensing receptor: A new target for therapy of diarrhea
Manuscript Source	Invited Manuscript
All Author List	Sam Xianjun Cheng
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health NICHD K08HD079674 CDNHF/NASPGHAN foundation 00102979
Corresponding Author	Sam Xianjun Cheng, MD, PhD, Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, University of Florida, 1600 SW Archer Road, RG 120, PO Box 100296, Gainesville, FL 32610, United States. sam.cheng@ufl.edu
Key Words	Secretory diarrhea; Inflammatory diarrhea; Oral rehydration solution; Anti-secretory; Pro-absorptive; Intestinal permeability; Intestinal barrier function; Enteric nervous system; Cholera toxin; Escherichia coli heat stable toxin
Core Tip	Diarrheal disease remains a leading cause of death in children and the elderly throughout the world. The cause of death is dehydration secondary to severe diarrhea. Intestinal calcium-sensing receptor (CaSR) is a newly uncovered ancient antidiarrheal receptor system that appears to exert profound effects not only on intestinal secretion, absorption and motility but also on gut permeability and inflammatory responses. Activating this unusual machinery reverses pathophysiological changes of both secretory and inflammatory diarrheas. Considering its unique property of using simple nutrients as activators, it is now possible that through targeting of CaSR and developing novel oral rehydrating solutions that are inexpensive and practical to use in all countries, these diarrhea-associated deaths are reduced or eliminated.
Publish Date	2016-03-02 13:35
Citation	Cheng SX. Calcium-sensing receptor: A new target for therapy of diarrhea. World J Gastroenterol 2016; 22(9): 2711-2724
URL	http://www.wjgnet.com/1007-9327/full/v22/i9/2711.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i9.2711

Full Article (PDF)	WJG-22-2711.pdf
Full Article (Word)	WJG-22-2711.doc
Manuscript File	23014-Review.docx
Answering Reviewers	23014-Answering reviewers.pdf
Audio Core Tip	23014-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23014-Conflict-of-interest statement.pdf
Copyright License Agreement	23014-Copyright assignment.pdf
Peer-review Report	23014-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23014-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23014-Scientific misconduct check.pdf
Scientific Editor Work List	23014-Scientific editor work list.pdf