Publication Name	World Journal of Nephrology
Manuscript ID	23051
Country	United States

Received	2015-10-16 08:19
Peer-Review Started	2015-10-18 21:26
To Make the First Decision	2015-11-06 10:53
Return for Revision	2015-11-11 17:41
Revised	2015-11-20 00:50
Second Decision	2015-12-18 11:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-04 16:41
Articles in Press	2016-01-04 16:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 09:44
Publish the Manuscript Online	2016-03-01 14:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms
Manuscript Source	Invited Manuscript
All Author List	Jeffrey H William and John Danziger
Funding Agency and Grant Number
Corresponding Author	Jeffrey H William, MD, Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, 171 Pilgrim Road, Libby 2, Boston, MA 02215, United States. jhwillia@bidmc.harvard.edu
Key Words	Hypomagnesemia; Proton-pump inhibitor; Magnesium; Nephrology; Renal
Core Tip	Proton-pump inhibitor (PPI)-induced hypomagnesemia has become a well-recognized phenomenon over the past decade, through the publications of case reports and larger observational studies in the inpatient and outpatient populations. However, there are no prospective, controlled studies to support causation. Molecular mechanisms of magnesium transporters, including the pH-dependent regulation of transient receptor potential melastatin-6 transporters in the colonic enterocyte, have been proposed to explain the effect of PPIs on magnesium reabsorption, but may only comprise a small part of a more complicated interplay of molecular biology, pharmacology, and genetic predisposition.
Publish Date	2016-03-01 14:46
Citation	William JH, Danziger J. Proton-pump inhibitor-induced hypo¬magnesemia: Current research and proposed mechanisms. World J Nephrol 2016; 5(2): 152-157
URL	http://www.wjgnet.com/2220-6124/full/v5/i2/152.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i2.152

Full Article (PDF)	WJN-5-152.pdf
Full Article (Word)	WJN-5-152.doc
Manuscript File	23051-Review.docx
Answering Reviewers	23051-Answering reviewers.pdf
Audio Core Tip	23051-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23051-Conflict-of-interest statement.pdf
Copyright License Agreement	23051-Copyright assignment.pdf
Peer-review Report	23051-Peer-review(s).pdf
Scientific Misconduct Check	23051-Scientific misconduct check.pdf
Scientific Editor Work List	23051-Scientific editor work list.pdf