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2/25/2016 7:04:00 PM | Browse: 986 | Download: 1315
Publication Name World Journal of Gastroenterology
Manuscript ID 23117
Country/Territory Japan
Received
2015-10-27 10:09
Peer-Review Started
2015-10-27 21:15
To Make the First Decision
2015-11-27 16:48
Return for Revision
2015-11-30 09:41
Revised
2015-12-08 14:42
Second Decision
2015-12-11 11:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-21 14:03
Articles in Press
2015-12-21 14:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-31 13:33
Publish the Manuscript Online
2016-02-25 19:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice
Manuscript Source Unsolicited Manuscript
All Author List Takaya Yamamoto, Yukiomi Nakade, Taeko Yamauchi, Yuji Kobayashi, Norimitsu Ishii, Tomohiko Ohashi, Kiyoaki Ito, Ken Sato, Yoshitaka Fukuzawa and Masashi Yoneda
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sport, Science and Technology of Japan to Nakade Y and Yoneda M
Aikeikai Foundation
Corresponding Author Yukiomi Nakade, MD, PhD, Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University, 1-1 Karimata Yazako Nagakute Aichi 480-1195, Japan. ynakade@aichi-med-u.ac.jp
Key Words Glucagon like peptide-1; Nonalcoholic steatohepatitis; Kupffer cells; Free fatty acid; Oxidative stress
Core Tip Herein, we suggest that a glucagon-like peptide-1 (GLP-1) analogue inhibits nonalcoholic steatohepatitis (NASH), which is being increasingly recognized in Asia, in non-obese mice. A methionine-choline-deficient diet (MCD) was reported to induce steatohepatitis, which is morphologically similar to NASH. Additionally, it increases serum free fatty acid levels and hepatic free fatty acid and triglyceride content in mice. In our study, we showed for the first time that exendin-4, a novel GLP-1 analogue, improved steatohepatitis through the inhibition of hepatic free fatty acid influx and by suppression of macrophage recruitment and oxidative stress in our MCD-fed NASH model.
Publish Date 2016-02-25 19:03
Citation Yamamoto T, Nakade Y, Yamauchi T, Kobayashi Y, Ishii N, Ohashi T, Ito K, Sato K, Fukuzawa Y, Yoneda M. Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice. World J Gastroenterol 2016; 22(8): 2512-2523
URL http://www.wjgnet.com/1007-9327/full/v22/i8/2512.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i8.2512
Full Article (PDF) WJG-22-2512.pdf
Full Article (Word) WJG-22-2512.doc
Manuscript File 23117-Review.docx
Answering Reviewers 23117-Answering reviewers.pdf
Audio Core Tip 23117-Audio core tip.mp3
Biostatistics Review Certificate 23117-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 23117-Conflict-of-interest statement.pdf
Copyright License Agreement 23117-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 23117-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 23117-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 23117-Language certificate.pdf
Scientific Misconduct Check 23117-Scientific misconduct check.pdf
Scientific Editor Work List 23117-Scientific editor work list.pdf