ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Takaya Yamamoto, Yukiomi Nakade, Taeko Yamauchi, Yuji Kobayashi, Norimitsu Ishii, Tomohiko Ohashi, Kiyoaki Ito, Ken Sato, Yoshitaka Fukuzawa and Masashi Yoneda |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Ministry of Education, Culture, Sport, Science and Technology of Japan |
to Nakade Y and Yoneda M |
Aikeikai Foundation |
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Corresponding Author |
Yukiomi Nakade, MD, PhD, Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University, 1-1 Karimata Yazako Nagakute Aichi 480-1195, Japan. ynakade@aichi-med-u.ac.jp
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Key Words |
Glucagon like peptide-1; Nonalcoholic steatohepatitis; Kupffer cells; Free fatty acid; Oxidative stress |
Core Tip |
Herein, we suggest that a glucagon-like peptide-1 (GLP-1) analogue inhibits nonalcoholic steatohepatitis (NASH), which is being increasingly recognized in Asia, in non-obese mice. A methionine-choline-deficient diet (MCD) was reported to induce steatohepatitis, which is morphologically similar to NASH. Additionally, it increases serum free fatty acid levels and hepatic free fatty acid and triglyceride content in mice. In our study, we showed for the first time that exendin-4, a novel GLP-1 analogue, improved steatohepatitis through the inhibition of hepatic free fatty acid influx and by suppression of macrophage recruitment and oxidative stress in our MCD-fed NASH model.
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Publish Date |
2016-02-25 19:03 |
Citation |
Yamamoto T, Nakade Y, Yamauchi T, Kobayashi Y, Ishii N, Ohashi T, Ito K, Sato K, Fukuzawa Y, Yoneda M. Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice. World J Gastroenterol 2016; 22(8): 2512-2523 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i8/2512.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i8.2512 |