Publication Name	World Journal of Radiology
Manuscript ID	23139
Country	Canada

Received	2015-10-24 13:44
Peer-Review Started	2015-10-27 17:24
To Make the First Decision	2016-02-02 08:58
Return for Revision	2016-02-02 11:39
Revised	2016-02-13 02:45
Second Decision	2016-03-14 08:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-23 16:51
Articles in Press	2016-03-23 16:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-07 14:40
Publish the Manuscript Online	2016-06-18 17:56

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke?
Manuscript Source	Invited Manuscript
All Author List	Peggy Yen, Allison Cobb and Jai Jai Shiva Shankar
Funding Agency and Grant Number
Corresponding Author	Jai Jai Shiva Shankar, MD, Associate Professor of Medicine, Department of Diagnostic Radiology, Queen Elizabeth Ⅱ Health Sciences Centre, P.O. Box 9000, Halifax, Nova Scotia B3K 6A3, Canada. shivajai1@gmail.com
Key Words	Stroke; Mechanical thrombolysis; Cerebral hemorrhage; Capillary permeability; Thrombolytic therapy
Core Tip	Hemorrhagic transformation is one of the most important complications following thrombolytic treatment of acute ischemic stroke (AIS). Predicting hemorrhagic complication at presentation can be useful to clinicians. Perfusion-derived permeability-surface area product maps (PS) may help in predicting hemorrhagic transformation. We investigated whether PS can predict hemorrhagic transformation on follow-up. We found that pretreatment PS can predict the occurrence of hemorrhagic transformation on follow-up of AIS patients with relatively high sensitivity, specificity, positive and negative predictive value. However, it cannot predict the degree of severity, which is critical in the decision to treat.
Publish Date	2016-06-18 17:56
Citation	Yen P, Cobb A, Shankar JJS. Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke? World J Radiol 2016; 8(6): 594-599
URL	http://www.wjgnet.com/1949-8470/full/v8/i6/594.htm
DOI	http://dx.doi.org/10.4329/wjr.v8.i6.594

Full Article (PDF)	WJR-8-594.pdf
Full Article (Word)	WJR-8-594.doc
Manuscript File	23139-Review.doc
Answering Reviewers	23139-Answering reviewers.pdf
Audio Core Tip	23139-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20151024020101.docx
Conflict-of-Interest Disclosure Form	23139-Conflict-of-interest statement.pdf
Copyright License Agreement	23139-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	23139-Institutional review board statement.pdf
Peer-review Report	23139-Peer-review(s).pdf
Scientific Misconduct Check	23139-Scientific misconduct check.pdf
Scientific Editor Work List	23139-Scientific editor work list.pdf