| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yamilka Abreu-Delgado, Raymond A Isidro, Esther A Torres, Alexandra González, Myrella L Cruz, Angel A Isidro, Carmen I González-Keelan, Priscilla Medero and Caroline B Appleyard |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health Grants |
R25GM082406(to Isidro RA) |
| National Institutes of Health Grants |
U54CA163071(to Appleyard CB) |
| Office of Research from the Ponce Research Institute at Ponce Health Sciences University |
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| William Townsend Porter Predoctoral Fellowship from the American Physiological Society |
to Isidro RA |
| PHSU Molecular and Genomics Core Laboratory |
RR003050/MD007579 |
| Puerto Rico Clinical and Translational Research Consortium, National Institutes of Health Grant |
U54MD007587 (to Abreu Y, Medero P and Torres EA) |
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| Corresponding Author |
Caroline B Appleyard, PhD, Professor, Department of Basic Sciences, Physiology Division, Ponce Health Sciences University-Medical School and Ponce Research Institute, PO Box 7004, Ponce, PR 00732,
United States. cappleyard@psm.edu
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| Key Words |
Colitis; Inflammation; Vitamin D; Vitamin D receptor; Inflammatory bowel disease |
| Core Tip |
Our study examines for the first time the relationship between serum vitamin D levels, colonic vitamin D receptor (VDR) expression, and histologic disease activity. We show in Puerto Rican patients that colonic VDR expression and inflammation are negatively correlated in endoscopically and histologically diseased colon and that serum vitamin D levels positively correlate with VDR expression in endoscopically and histologically normal colon. These findings contribute to our understanding of the role of vitamin D and VDR in patients with inflammatory bowel disease and could affect the current care of these patients.
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| Publish Date |
2016-03-28 15:05 |
| Citation |
Abreu-Delgado Y, Isidro RA, Torres EA, González A, Cruz ML, Isidro AA, González-Keelan CI, Medero P, Appleyard CB. Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease. World J Gastroenterol 2016; 22(13): 3581-3591 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i13/3581.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i13.3581 |
