Publication Name	World Journal of Nephrology
Manuscript ID	23152
Country	Egypt

Received	2015-10-25 10:52
Peer-Review Started	2015-10-27 17:19
To Make the First Decision	2016-01-14 17:05
Return for Revision	2016-01-18 13:58
Revised	2016-01-26 00:00
Second Decision	2016-02-15 17:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-02-24 14:27
Articles in Press	2016-02-24 14:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-06 17:03
Publish the Manuscript Online	2016-04-25 20:53

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Stop chronic kidney disease progression: Time is approaching
Manuscript Source	Invited Manuscript
All Author List	Usama Abdel Azim Sharaf El Din, Mona Mansour Salem and Dina Ossama Abdulazim
Funding Agency and Grant Number
Corresponding Author	Usama Abdel Azim Sharaf El Din, MD, Professor, Departments of Nephrology, School of Medicine, Cairo University, 58th Abbas El Akkad St., Manial, Cairo 11759, Egypt. usamaaas@gmail.com
Key Words	Chronic kidney disease; Progression; Klotho; Amyloidosis; Diabetic nephropathy; Micro RNA
Core Tip	The problem of chronic kidney disease (CKD) progression is a panic, affecting both patients and physicians. The fact that such patients will sooner or later need RRT terrifies them and makes these patients to survive a continuous mare. All the trials to stop this progression in the past only delayed this progression for some time. However, in the last 2 years many genuine experimental and clinical trials revived the hope to stop the progression almost completely in the vast variety of chronic renal diseases. In this review, we are highlighting most of these trials, stressing on the different mechanisms that would stop CKD progression.
Publish Date	2016-04-25 20:53
Citation	Sharaf El Din UAA, Salem MM, Abdulazim DO. Stop chronic kidney disease progression: Time is approaching. World J Nephrol 2016; 5(3): 258-273
URL	http://www.wjgnet.com/2220-6124/full/v5/i3/258.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i3.258

Full Article (PDF)	WJN-5-258.pdf
Full Article (Word)	WJN-5-258.doc
Manuscript File	23152-Review.docx
Answering Reviewers	23152-Answering reviewers.pdf
Audio Core Tip	23152-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	23152-Conflict-of-interest statement.pdf
Copyright License Agreement	23152-Copyright assignment.pdf
Peer-review Report	23152-Peer-review(s).pdf
Scientific Misconduct Check	23152-Scientific misconduct check.pdf
Scientific Editor Work List	23152-Scientific editor work list.pdf