Publication Name	World Journal of Gastroenterology
Manuscript ID	23204
Country	China

Received	2015-10-30 08:47
Peer-Review Started	2015-10-30 09:22
First Decision by Editorial Office Director
Return for Revision	2015-11-30 09:25
Revised	2015-12-13 23:32
Publication Fee Transferred
Second Decision by Editor	2015-12-18 15:26
Second Decision by Editor-in-Chief	2015-12-18 15:54
Final Decision by Editorial Office Director	2015-12-30 17:39
Articles in Press	2015-12-30 17:39
Edit the Manuscript by Language Editor	2016-02-24 07:43
Typeset the Manuscript	2016-03-15 17:50
Publish the Manuscript Online	2016-03-28 15:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Genetic variation of occult hepatitis B virus infection
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Lan Zhu, Xu Li, Jun Li and Zhen-Hua Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Specialized Research Fund for the Doctoral Program of Higher Education of China 20093420120005 National Science Foundation of China 81273142
Corresponding Author	Zhen-hua Zhang, MD, PhD, Department of Infectious Diseases, the First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei 230022, Anhui Province, China. zzh1974cn@163.com
Key Words	Hepatitis B virus; Occult; Variation; Hepatitis B surface antigen
Core Tip	With error-prone reverse transcription during replication, hepatitis B virus (HBV) displays a high rate of mutation, and a single mutation may affect the biological properties of HBV. Occult HBV infection (OBI) is a special form of HBV infection and a frequent phenomenon. Many previous publications have explored the association of OBI with the “hot spots” mutations that occur within the immunodominant “α” determinant of S proteins. However, there are no reviews available that elaborate on the relationship between OBI and mutations throughout the entire HBV genome. This review attempts to provide a comprehensive summary of HBV genetic variants that have been associated with OBI.
Publish Date	2016-03-28 15:05
Citation	Zhu HL, Li X, Li J, Zhang ZH. Genetic variation of occult hepatitis B virus infection. World J Gastroenterol 2016; 22(13): 3531-3546
URL	http://www.wjgnet.com/1007-9327/full/v22/i13/3531.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i13.3531

Full Article (PDF)	WJG-22-3531.pdf
Full Article (Word)	WJG-22-3531.doc
Manuscript File	23204-Review.docx
Answering Reviewers	23204-Answering reviewers.pdf
Audio Core Tip	23204-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23204-Conflict-of-interest statement.pdf
Copyright License Agreement	23204-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	23204-Language certificate.pdf
Peer-review Report	23204-Peer-review(s).pdf
Scientific Misconduct Check	23204-Scientific misconduct check.pdf
Scientific Editor Work List	23204-Scientific editor work list.pdf