Publication Name	World Journal of Hematology
Manuscript ID	23508
Country	Netherlands

Received	2015-11-26 16:25
Peer-Review Started	2015-11-30 10:18
To Make the First Decision	2016-01-14 17:11
Return for Revision	2016-01-15 16:54
Revised
Second Decision	2016-04-08 09:52
Accepted by Journal Editor-in-Chief	2016-04-08 10:12
Accepted by Executive Editor-in-Chief	2016-04-18 13:41
Articles in Press	2016-04-18 13:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-04-26 04:49
Typeset the Manuscript	2016-08-04 15:33
Publish the Manuscript Online	2016-08-06 17:31

ISSN	2218-6204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Changing insights in the diagnosis and classification of autosomal recessive and dominant von Willebrand diseases 1980-2015
Manuscript Source	Invited Manuscript
All Author List	Jan Jacques Michiels, Angelika Batorova, Tatiana Prigancova, Petr Smejkal, Miroslav Penka, Inge Vangenechten and Alain Gadisseur
Funding Agency and Grant Number
Corresponding Author	Jan Jacques Michiels, MD, PhD, Investigator, Senior Internist, Goodheart Institute and Foundation in Nature Medicine and Health, Blood Coagulation and Vascular Medicine Research Center, Erasmus Tower, Veenmos 13, 3069 Rotterdam, The Netherlands. goodheartcenter.@upcmail.nl
Key Words	Von Willebrand disease; Von Willebrand factor; ADAMTS13; DDAVP; Von Willebrand factor assays; Von Willebrand gene mutations
Core Tip	The European Clinical Laboratory and Mole-cular criteria define at least 10 distinct phenotypes of von Willebrand diseases (VWD) that have significant therapeutic implications. High quality von Willebrand factor (VWF) multimeric analysis and responses to desmopressin of FVIII:C and VWF parameters are of critical diagnostic importance to document the contribution of VWF secretion, clearance, proteolysis and multimerization defects to real life phenotyping of each individual VWD patient.
Publish Date	2016-08-06 17:31
Citation	Michiels JJ, Batorova A, Prigancova T, Smejkal P, Penka M, Vangenechten I, Gadisseur A. Changing insights in the diagnosis and classification of autosomal recessive and dominant von Willebrand diseases 1980-2015. World J Hematol 2016; 5(3): 61-74
URL	http://www.wjgnet.com/2218-6204/full/v5/i3/61.htm
DOI	http://dx.doi.org/10.5315/wjh.v5.i3.61

Full Article (PDF)	WJH-5-61.pdf
Full Article (Word)	WJH-5-61.doc
Manuscript File	23508-Review.docx
Answering Reviewers	23508-Answering reviewers.pdf
Audio Core Tip	23508-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23508-Conflict-of-interest statement.pdf
Copyright License Agreement	23508-Copyright assignment.pdf
Peer-review Report	23508-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23508-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23508-Scientific misconduct check.pdf
Scientific Editor Work List	23508-Scientific editor work list.pdf