Publication Name	World Journal of Gastroenterology
Manuscript ID	2386
Country	United States

Received	2013-02-19 11:04
Peer-Review Started	2013-02-20 08:35
To Make the First Decision	2013-03-11 15:12
Return for Revision	2013-03-15 10:36
Revised	2013-04-24 21:17
Second Decision	2013-06-06 09:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-06 12:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-07 18:33
Publish the Manuscript Online	2013-08-19 18:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Nutrition & Dietetics
Manuscript Type	Autobiography
Article Title	Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets
Manuscript Source	Invited Manuscript
All Author List	Sheila K Jacobi, Adam J Moeser, Anthony T Blikslager, J Marc Rhoads, Benjamin A Corl, Robert J Harrell and Jack Odle
Funding Agency and Grant Number	Funding Agency Grant Number Cooperative State Research, Education and Extension Service, USDA-National Research Initiative 2005-35200-16174 North Carolina Agriculture Research Service
Corresponding Author	Jack Odle, PhD, Professor, Laboratory of Developmental Nutrition, College of Agriculture and Life Sciences, North Carolina State University, 2200 Hillsborough, Box 7621, Raleigh, NC 27695, United States. jack_odle@ncsu.edu
Key Words	Rotavirus gastroenteritis; Kwashiorkor; Occludin; Ussing chamber; Villus
Core Tip	We are quite excited about these results which suggest involvement of intestinal tight-junction proteins in the pathology of rotaviral gastroenteritis. The work further examines the interplay of malnutrition superimposed on viral infection. 3H-mannitol flux was significantly increased in rotavirus infected piglets compared to non-infected piglets, but there was no effect of nutritional status. Furthermore, rotavirus infection reduced localization of the tight junction protein, occludin, in the cell membrane and increased localization in the cytosol. This extends work on the molecular mechanisms of rotavirus in the neonatal intestine that we previously published.
Publish Date	2013-08-19 18:22
Citation	Jacobi SK, Moeser AJ, Blikslager AT, Rhoads JM, Corl BA, Harrell RJ, Odle J. Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets. World J Gastroenterol 2013; 19(31): 5094-5102
URL	http://www.wjgnet.com/1007-9327/full/v19/i31/5094.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i31.5094

Full Article (PDF)	WJG-19-5094.pdf
Manuscript File	2386-Review.doc
Answering Reviewers	2386-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician Review Report.docx
Copyright License Agreement	2386-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics Committee Approval Document.docx
Peer-review Report	2386-Peer review(s).pdf
Scientific Editor Work List	2386-Scientific editor work list.doc