Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	24003
Country	United States

Received	2015-12-30 08:20
Peer-Review Started	2016-01-02 13:36
To Make the First Decision	2016-02-02 08:46
Return for Revision	2016-02-02 09:38
Revised	2016-03-01 04:41
Second Decision	2016-03-07 15:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-18 15:59
Articles in Press	2016-03-18 15:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-22 16:30
Publish the Manuscript Online	2016-05-12 16:59

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine
Manuscript Source	Invited Manuscript
All Author List	Katherine M DiGuilio, Christina M Mercogliano, Jillian Born, Brendan Ferraro, Julie To, Brittany Mixson, Allison Smith, Mary Carmen Valenzano and James M Mullin
Funding Agency and Grant Number
Corresponding Author	James M Mullin, PhD, AGAF, Professor, Lankenau Institute for Medical Research, Lankenau Medical Center, 100 Lancaster Avenue, Wynnewood, PA 19096, United States. mullinj@mlhs.org
Key Words	Intestine; Crohn’s disease; Tight junction; Ulcerative colitis; CACO-2; Berberine; Micronutrient; Cytokine
Core Tip	A cell culture model of graded transepithelial leak can be very valuable in evaluating the various types and magnitudes of leak that can exhibit across the inflammatory bowel disease mucosa. This graded leak can be achieved through various combinations of proinflammatory cytokines and peroxide. Berberine provides an example of a micronutrient that can be more effective against one type of induced leak than another.
Publish Date	2016-05-12 16:59
Citation	DiGuilio KM, Mercogliano CM, Born J, Ferraro B, To J, Mixson B, Smith A, Valenzano MC, Mullin JM. Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine. World J Gastrointest Pathophysiol 2016; 7(2): 223-234
URL	http://www.wjgnet.com/2150-5330/full/v7/i2/223.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i2.223

Full Article (PDF)	WJGP-7-223.pdf
Full Article (Word)	WJGP-7-223.doc
Manuscript File	24003-Review.docx
Answering Reviewers	24003-Answering reviewers.pdf
Audio Core Tip	24003-Audio core tip.mp3
Biostatistics Review Certificate	24003-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24003-Conflict-of-interest statement.pdf
Copyright License Agreement	24003-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151230003201.docx
Institutional Animal Care and Use Committee Approval Form or Document	24003-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	24003-Institutional review board statement.pdf
Supplementary Material	Supplementary_Material_20151230003219.docx
Peer-review Report	24003-Peer-review(s).pdf
Scientific Misconduct Check	24003-Scientific misconduct check.pdf
Scientific Editor Work List	24003-Scientific editor work list.pdf