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6/13/2016 9:08:00 AM | Browse: 411 | Download: 386
Publication Name World Journal of Orthopedics
Manuscript ID 24117
Country/Territory Spain
2016-01-10 17:11
Peer-Review Started
2016-01-12 08:45
To Make the First Decision
2016-03-01 09:13
Return for Revision
2016-03-01 15:49
2016-03-10 00:00
Second Decision
2016-04-12 17:11
Accepted by Journal Editor-in-Chief
2016-04-14 22:37
Accepted by Company Editor-in-Chief
2016-04-22 16:27
Articles in Press
2016-04-22 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-19 11:57
Publish the Manuscript Online
2016-06-13 09:08
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Minireviews
Article Title Orthopedic disorders of the knee in hemophilia: A current concept review
Manuscript Source Invited Manuscript
All Author List E Carlos Rodriguez-Merchan and Leonard A Valentino
Funding Agency and Grant Number
Corresponding author E Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana 261, 28046 Madrid, Spain. ecrmerchan@gmx.es
Keywords Hemophilia; Knee; Orthopedic problems; Prevention; Surgical treatment
Core Tip Hemophilia is an inherited bleeding disorder due to deficiency of factor Ⅷ (hemophilia A) or factor Ⅸ (hemophilia B) resulting in insufficient thrombin generation leading to recurrent intra-articular hemorr-hages (hemarthroses). Prevention of hemarthroses with intravenous infusions of the deficient protein from infancy to adulthood (primary prophylaxis) should be considered to achieve optimal outcomes. If factor replacement therapy (FRT) is insufficient, or if patients are not adherent to the prescribed regimen, recurrent hemarthroses results in chondrocyte apoptosis (cartilage degeneration) and hypertrophy of the synovium (syno-vitis). Many surgical interventions are available for the knee joint. For example, to treat synovitis recalcitrant to FRT, there are two primary orthopedic modalities: Radiosynovectomy and arthroscopic synovectomy. This article reviews the pathogenesis, diagnosis and treat-ment of hemophilic arthropathy of the knee.
Publish Date 2016-06-13 09:08
Citation Rodriguez-Merchan EC, Valentino LA. Orthopedic disorders of the knee in hemophilia: A current concept review. World J Orthop 2016; 7(6): 370-375
Url http://www.wjgnet.com/2218-5836/full/v7/i6/370.htm
DOI http://dx.doi.org/10.5312/wjo.v7.i6.370
Full Article (PDF) WJO-7-370.pdf
Full Article (Word) WJO-7-370.doc
Manuscript File 24117-Review.doc
Answering Reviewers 24117-Answering reviewers.pdf
Audio Core Tip 24117-Audio core tip.m4a
Biostatistics Review Certificate Biostatistics_Statement_20160108001322.doc
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20160108000907.doc
Conflict-of-Interest Disclosure Form 24117-Conflict-of-interest statement.pdf
Copyright License Agreement 24117-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160108000718.doc
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20160108001147.doc
Institutional Review Board Approval Form or Document Institutional_Review_Board_Statement_20160108000604.doc
Non-Native Speakers of English Editing Certificate 24117-Language certificate.pdf
Peer-review Report 24117-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24117-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24117-Scientific misconduct check.pdf
Scientific Editor Work List 24117-Scientific editor work list.pdf