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Articles Published Processes
5/4/2016 10:08:00 AM | Browse: 1269 | Download: 3256
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Received |
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2016-01-21 11:55 |
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Peer-Review Started |
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2016-01-21 16:49 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-02-19 11:19 |
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Revised |
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2016-03-02 18:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-03-04 18:03 |
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Second Decision by Editor-in-Chief |
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2016-03-05 15:54 |
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Final Decision by Editorial Office Director |
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2016-03-14 10:22 |
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Articles in Press |
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2016-03-14 10:22 |
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Edit the Manuscript by Language Editor |
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2016-03-28 01:59 |
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Typeset the Manuscript |
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2016-04-07 09:10 |
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Publish the Manuscript Online |
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2016-05-04 10:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Peer-review started: February 25, 2016 |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nicoletta Gagliano, Giuseppe Celesti, Lorenza Tacchini, Stefano Pluchino, Chiarella Sforza, Marco Rasile, Vincenza Valerio, Luigi Laghi, Vincenzo Conte and Patrizia Procacci |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Milan (Project B grant) |
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| Corresponding Author |
Nicoletta Gagliano, PhD, Associate Professor of Histology, Department of Biomedical Sciences for Health, Università degli Studi di Milano, via Mangiagalli 31, 20133 Milan, Italy. nicoletta.gagliano@unimi.it |
| Key Words |
Epithelial-to-mesenchymal transition; E-cadherin; 3D-spheroids; Podoplanin; Pancreatic ductal adenocarcinoma |
| Core Tip |
The functions of living tissue can be mimicked by three-dimensional (3D) cell cultures, thereby providing a method of decoding the information encoded in the tissue architecture. We aimed to analyze the effect of 3D-arrangement on the expression of some key markers of epithelial-to-mesenchymal transition in pancreatic adenocarcinoma (PDAC) cells cultured in either 2D-monolayers or 3D-spheroids. Our results show that a 3D-cell culture model could provide deeper insight into understanding the biology of PDAC and allow for the detection of marked differences in the phenotype of PDAC cells grown in 3D-spheroids. |
| Publish Date |
2016-05-04 10:08 |
| Citation |
Gagliano N, Celesti G, Tacchini L, Pluchino S, Sforza C, Rasile M, Valerio V, Laghi L, Conte V, Procacci P. Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model. World J Gastroenterol 2016; 22(18): 4466-4483 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i18/4466.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i18.4466 |
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