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Articles Published Processes
6/2/2016 3:32:00 PM | Browse: 917 | Download: 1832
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Received |
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2016-02-09 11:04 |
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Peer-Review Started |
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2016-02-09 12:23 |
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To Make the First Decision |
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2016-03-07 08:33 |
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Return for Revision |
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2016-03-08 16:13 |
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Revised |
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2016-03-23 04:06 |
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Second Decision |
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2016-03-30 16:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-04-07 16:04 |
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Articles in Press |
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2016-04-07 16:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-11 17:47 |
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Publish the Manuscript Online |
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2016-06-02 15:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Structural and molecular features of intestinal strictures in rats with Crohn's-like disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Petra Talapka, Anikó Berkó, Lajos István Nagy, Lalitha Chandrakumar, Mária Bagyánszki, László Géza Puskás, Éva Fekete and Nikolett Bódi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hungarian Scientific Research Fund |
OTKA PD 108309 |
| János Bolyai Research Scholarship of the Hungarian Academy of Sciences to Bagyánszki M |
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| Corresponding Author |
Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences and Informatics, University of Szeged, H-6726 Szeged, Közép fasor 52, Hungary. bmarcsi@bio.u-szeged.hu
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| Key Words |
Crohn’s disease; Rat model; TGF-beta; Intestinal strictures; MMP9; TIMP1 |
| Core Tip |
Intestinal strictures in Crohn’s disease (CD) cause hardly treatable complications in patients. The aim of this study was to find the correlation be-tween the intestinal stricture formation, the damaged innervation of smooth muscle cells (SMCs) and the changed expression of TGF-beta 2, 3 and MMP9/TIMP1 in rats with CD by using different light- and electron microscopic and molecular biological methods. Our findings indicate that disintegration of SMCs due to the up-regulation of TGF-beta 2 and off-balance in MMP9/TIMP1 expression rather than neuronal cell death play the primary role in the formation of intestinal strictures in CD.
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| Publish Date |
2016-06-02 15:26 |
| Citation |
Talapka P, Berkó A, Nagy LI, Chandrakumar L, Bagyánszki M, Puskás LG, Fekete E, Bódi N. Structural and molecular features of intestinal strictures in rats with Crohn’s-like disease. World J Gastroenterol 2016; 22(22): 5154-5164 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i22/5154.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i22.5154 |
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