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Articles Published Processes
5/30/2016 5:39:00 PM | Browse: 1093 | Download: 2101
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Received |
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2016-01-15 16:22 |
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Peer-Review Started |
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2016-01-18 14:42 |
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To Make the First Decision |
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2016-02-18 16:55 |
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Return for Revision |
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2016-02-20 16:15 |
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Revised |
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Second Decision |
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2016-03-31 10:23 |
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Accepted by Journal Editor-in-Chief |
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2016-04-01 01:48 |
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Accepted by Executive Editor-in-Chief |
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2016-04-07 15:54 |
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Articles in Press |
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2016-04-07 15:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-04-11 12:05 |
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Publish the Manuscript Online |
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2016-05-30 17:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Multiorgan chronic inflammatory hepatobiliary pancreatic murine model deficient in tumor necrosis factor receptors 1 and 2
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Helieh S Oz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R03-DE019177 |
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| Corresponding Author |
Helieh S Oz, DVM, PhD, AGAF, Department of Physiology and Internal Medicine, College of Medicine, University of Kentucky Medical Center, Lexington, KY 40536, United States. hoz2@email.uky.edu |
| Key Words |
Inflammatory pain; Multiorgan; Hepatitis; Pancreatitis; Calculi formation; Gall bladder; Hepatobiliary inflammation |
| Core Tip |
Currently there is no reliable model for chronic multiorgan inflammatory and fibrosis. Tumor necrosis factor (TNF)a initiates inflammation through TNFR1/R2. TNFR1/R2 deficient mice administered orally with dibutyltin dichloride (DBTC) developed significant persistent inflammatory and pain related secondary mechanical hypersensitivity. DBTC-animals showed severe chronic hepatobiliary injuries and prominent biliary ductal dilation. Extensive fibrotic thickening was evidenced around portal ducts, in hepatic and pancreatic structures. DBTC-animals had severe pancreatic damage and pancreatitis, hepatic lesions with expansion of gall bladder, bile stones and severe colitis. This is the first report of chronic inflammatory multiorgan hepatobiliary pancreatitis, fibrosis and calculi formation in TNFR1/R2 deficient mice. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
Oz HS. Multiorgan chronic inflammatory hepatobiliary pancreatic murine model deficient in tumor necrosis factor receptors 1 and 2. World J Gastroenterol 2016; 22(21): 4988-4998 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/4988.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.4988 |
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