Publication Name	World Journal of Gastroenterology
Manuscript ID	24318
Country	Iran

Received	2016-01-18 08:46
Peer-Review Started	2016-01-19 09:16
To Make the First Decision	2016-02-18 16:56
Return for Revision	2016-02-20 17:57
Revised	2016-02-27 19:59
Second Decision	2016-03-04 18:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-03-14 09:42
Articles in Press	2016-03-14 09:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-04-12 11:35
Typeset the Manuscript	2016-04-27 11:24
Publish the Manuscript Online	2016-05-17 10:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy
Manuscript Source	Invited Manuscript
All Author List	Seyed Soheil Saeedi Saravi, Mahmoud Ghazi-Khansari, Shahram Ejtemaei Mehr, Maliheh Nobakht, Seyyedeh Elaheh Mousavi and Ahmad Reza Dehpour
Funding Agency and Grant Number	Funding Agency Grant Number Tehran University of Medical Sciences and Health Services grant 92033024196
Corresponding Author	Ahmad Reza Dehpour, PharmD, PhD, Professor, Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran 13145, Iran. dehpour@yahoo.com
Key Words	Cirrhotic cardiomyopathy; Rat; mammalian target of rapamycin; Rapamycin; Inotropic effect
Core Tip	Enhanced levels of cardiac phosphorylated mammalian target of rapamycin (mTOR) contribute to impairment of electrophysiological and mechanical function induced by cirrhosis, called “cirrhotic cardio-myopathy”. Here, we find that the mTOR inhibitor rapamycin normalized the impaired inotropic respon-siveness to β-adrenergic stimulation and prolonged Q-T interval in tetrachloride carbon (CCl4)-induced cirrhotic rats. Cardiac ventricular expression of phosphorylated-mTOR (p-mTOR) was increased in rats with cirrhosis, and this effect was ameliorated by rapamycin. CCl4-induced cirrhosis was associated with an increase in cardiac proinflammatory cytokine tumor necrosis factor-α, and this increase was reversed by rapamycin as well.
Publish Date	2016-05-17 10:45
Citation	Saeedi Saravi SS, Ghazi-Khansari M, Ejtemaei Mehr S, Nobakht M, Mousavi SE, Dehpour AR. Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy. World J Gastroenterol 2016; 22(19): 4685-4694
URL	http://www.wjgnet.com/1007-9327/full/v22/i19/4685.htm
DOI	http://www.wjgnet.com/1007-9327/full/v22/i19/4685.htm

Manuscript File	24318-Review.docx
Answering Reviewers	24318-Answering reviewers.pdf
Audio Core Tip	24318-Audio core tip.wav
Biostatistics Review Certificate	24318-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24318-Conflict-of-interest statement.pdf
Copyright License Agreement	24318-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	24318-Grant application form.pdf
Institutional Animal Care and Use Committee Approval Form or Document	24318-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	24318-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	24318-Language certificate.pdf
Peer-review Report	24318-Peer-review(s).pdf
Scientific Misconduct Check	24318-Scientific misconduct check.pdf
Scientific Editor Work List	24318-Scientific editor work list.pdf