Publication Name	World Journal of Gastroenterology
Manuscript ID	24816
Country	United States

Received	2016-02-10 14:51
Peer-Review Started	2016-02-10 19:40
To Make the First Decision	2016-03-07 08:31
Return for Revision	2016-03-08 16:31
Revised	2016-03-28 18:53
Second Decision	2016-04-26 12:06
Accepted by Journal Editor-in-Chief	2016-04-28 23:00
Accepted by Executive Editor-in-Chief	2016-05-23 16:47
Articles in Press	2016-05-23 16:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-21 10:33
Publish the Manuscript Online	2016-07-29 20:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review
Manuscript Source	Unsolicited Manuscript
All Author List	Tyler J Severson, Siddesh Besur and Herbert L Bonkovsky
Funding Agency and Grant Number
Corresponding Author	Herbert L Bonkovsky, MD, Professor, Department of Gastroenterology and Hepatology, Wake Forest University NC Baptist Medical Center, Nutrition Bldg, E-112, 1 Medical Center Blvd, Winston-Salem, NC 27157, United States. hbonkovs@wakehealth.edu
Key Words	Genetic polymorphisms; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; PNPLA3; TM6SF2; FTO; Cirrhosis; Iron metabolism
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions not only in the United States but worldwide. Its end results can include non-alcoholic steatohepatitis, cirrhosis, liver failure, and hepatocellular carcinoma. Studies since 2008 have demonstrated and continue to uncover noteworthy genetic factors that influence NAFLD and its onset, severity, and ultimate outcome. Awareness of these genetic elements yields improved understanding of the pathology of the disease and will likely be key to individualizing effective patient therapy in the near future.
Publish Date	2016-07-29 20:32
Citation	Severson TJ, Besur S, Bonkovsky HL. Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review. World J Gastroenterol 2016; 22(29): 6742-6756
URL	http://www.wjgnet.com/1007-9327/full/v22/i29/6742.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i29.6742

Full Article (PDF)	WJG-22-6742.pdf
Full Article (Word)	WJG-22-6742.doc
Manuscript File	24816-Review.docx
Answering Reviewers	24816-Answering reviewers.pdf
Audio Core Tip	24816-Audio core tip.wav
Biostatistics Review Certificate	24816-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24816-Conflict-of-interest statement.pdf
Copyright License Agreement	24816-Copyright assignment.pdf
Peer-review Report	24816-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24816-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24816-Scientific misconduct check.pdf
Scientific Editor Work List	24816-Scientific editor work list.pdf