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        6/2/2016 3:32:00 PM | Browse: 1125 | Download: 2577
    
    
        
        
    
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                    |  | Received |  | 2016-02-18 09:23 | 
    
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                    |  | Peer-Review Started |  | 2016-02-19 13:50 | 
    
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                    |  | To Make the First Decision |  | 2016-03-31 09:51 | 
    
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                    |  | Return for Revision |  | 2016-04-01 11:25 | 
    
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                    |  | Revised |  | 2016-04-26 12:26 | 
    
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                    |  | Second Decision |  | 2016-04-28 09:27 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  |  | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2016-05-04 18:32 | 
    
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                    |  | Articles in Press |  | 2016-05-04 18:32 | 
    
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                    |  | Publication Fee Transferred |  |  | 
    
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                    |  | Edit the Manuscript by Language Editor |  |  | 
    
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                    |  | Typeset the Manuscript |  | 2016-05-23 16:20 | 
            
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                            |  | Publish the Manuscript Online |  | 2016-06-02 15:26 | 
        
        
            
                | ISSN | 1007-9327 (print) and 2219-2840 (online) | 
            
                | Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | 
            
                | Copyright | © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Immunology | 
    
        | Manuscript Type | Basic Study | 
    
        | Article Title | Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱ expression on dendritic cells in chronic hepatitis C infection | 
    
        | Manuscript Source | Invited Manuscript | 
    
        | All Author List | Shallu Tomer, Yogesh K Chawla, Ajay Duseja and Sunil K Arora | 
    
        | Funding Agency and Grant Number | 
                        
                            
                                | Funding Agency | Grant Number |  
                                        | Council of Scientific and Industrial Research | 27 (0262) 12/EMR-II |  | 
    
        | Corresponding Author | Sunil K Arora, MSc, PhD, MNAMS, Professor, Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. arora.sunil@pgimer.edu.in | 
    
        | Key Words | Dendritic cells; Hepatitis C; Non-responders; Negative regulators; major histocompatibility complex Class-Ⅱ genes | 
    
        | Core Tip | The study was aimed to understand the mechanisms of dendritic cells dysfunction during chronic hepatitis C (CHC) infection. The findings highlight the association between different immune response genes and viral persistence in non-responders to antiviral therapy. Up regulation of negative regulators and down-regulation of molecules involved with antigen presentation seems to associate with non-responsiveness to antiviral therapy. Some novel pathways can be targeted to achieve better management of CHC patients. | 
            
                | Publish Date | 2016-06-02 15:26 | 
    
        | Citation | Tomer S, Chawla YK, Duseja A, Arora SK. Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱ expression on dendritic cells in chronic hepatitis C infection. World J Gastroenterol 2016; 22(22): 5173-5182 | 
            
                | URL | http://www.wjgnet.com/1007-9327/full/v22/i22/5173.htm | 
            
                | DOI | http://dx.doi.org/10.3748/wjg.v22.i22.5173 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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