Publication Name	World Journal of Radiology
Manuscript ID	25139
Country	Japan

Received	2016-02-25 09:24
Peer-Review Started	2016-02-27 13:50
To Make the First Decision	2016-05-13 16:24
Return for Revision	2016-05-13 17:02
Revised	2016-06-02 10:46
Second Decision	2016-07-20 17:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-01 15:58
Articles in Press	2016-08-01 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-08-04 07:16
Typeset the Manuscript	2016-09-22 18:52
Publish the Manuscript Online	2016-09-27 13:42

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine
Manuscript Source	Invited Manuscript
All Author List	Jun Toyohara
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science 25293271
Corresponding Author	Jun Toyohara, PhD, Theme Leader, Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. toyohara@pet.tmig.or.jp
Key Words	4′-[methyl-11C]-thiothymidine; DNA syn­thesis; Cell proliferation; Tumor; Positron emission tomography
Core Tip	There is a continuous demand to measure in situ DNA synthesis rates in living human cancer. The thymidine derivative 4′-[methyl-11C] thiothymidine (11C-4DST) has the potential to visualize in vivo DNA synthesis rates with positron emission tomography (PET). To confirm whether 11C-4DST is a valid DNA synthesis marker, clinical and basic research is being conducted at several PET centers in Japan, European Union, and the United States. This mini-review sum-marizes the progress of recent studies involving the in vivo imaging of cancer DNA synthesis using 11C-4DST PET.
Publish Date	2016-09-27 13:42
Citation	Toyohara J. Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine. World J Radiol 2016; 8(9): 799-808
URL	http://www.wjgnet.com/1949-8470/full/v8/i9/799.htm
DOI	http://dx.doi.org/10.4329/wjr.v8.i9.799

Full Article (PDF)	WJR-8-799.pdf
Full Article (Word)	WJR-8-799.doc
Manuscript File	25139-Review.docx
Answering Reviewers	25139-Answering reviewers.pdf
Audio Core Tip	25139-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	25139-Conflict-of-interest statement.pdf
Copyright License Agreement	25139-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25139-Grant application form(s).pdf
Peer-review Report	25139-Peer-review(s).pdf
Scientific Misconduct Check	25139-Scientific misconduct check.pdf
Scientific Editor Work List	25139-Scientific editor work list.pdf