Publication Name	World Journal of Clinical Cases
Manuscript ID	25152
Country	Italy

Received	2016-02-25 08:41
Peer-Review Started	2016-02-26 10:32
To Make the First Decision	2016-03-23 11:07
Return for Revision	2016-03-24 10:50
Revised	2016-05-25 00:00
Second Decision	2016-06-12 10:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-29 09:37
Articles in Press	2016-06-29 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-08 17:09
Publish the Manuscript Online	2016-10-14 10:12

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Hematology
Manuscript Type	Case Report
Article Title	Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib
Manuscript Source	Unsolicited Manuscript
All Author List	Paolo Fraticelli, Alain Kafyeke, Massimo Mattioli, Giuseppe Pio Martino, Marta Murri and Armando Gabrielli
Funding Agency and Grant Number
Corresponding Author	Paolo Fraticelli, MD, Clinica Medica, Department of Internal Medicine, Università Politecnica delle Marche, Ospedali Riuniti, via Conca, 60020 Ancona, Italy. paolo.fraticelli@ospedaliriuniti.marche.it
Key Words	Idiopathic hypereosinophilic syndrome; Eosinophilia; Cerebral vasculitis; PDGFR molecular rearrangement; Imatinib mesilate
Core Tip	Imatinib mesilate is the mainstay therapy of hypereosinophilic syndrome (HES) associated with molecular rearrangement of the PDGFR gene. To date, HES has been associated with more than 50 different fusion genes resulting from various chromosomal and molecular abnormalities, highlighting the fundamental role of constitutively activated tyrosine kinases in the pathogenesis of this disease; however, few of these genes are routinely researched or detected in the clinical setting. We report a case of HES that showed no evidence of PDGFR rearrangement but responded quickly and effectively to the small molecule kinase inhibitor drug, imatinib mesilate.
Publish Date	2016-10-14 10:12
Citation	Fraticelli P, Kafyeke A, Mattioli M, Martino GP, Murri M, Gabrielli A. Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib. World J Clin Cases 2016; 4(10): 328-332
URL	http://www.wjgnet.com/2307-8960/full/v4/i10/328.htm
DOI	http://dx.doi.org/10.12998/wjcc.v4.i10.328

Full Article (PDF)	WJCC-4-328.pdf
Full Article (Word)	WJCC-4-328.doc
Manuscript File	25152-Review.docx
Answering Reviewers	25152-Answering reviewers.pdf
Audio Core Tip	25152-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25152-Conflict-of-interest statement.pdf
Copyright License Agreement	25152-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	25152-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25152-Language certificate.pdf
Peer-review Report	25152-Peer-review(s).pdf
Scientific Misconduct Check	25152-Scientific misconduct check.pdf
Scientific Editor Work List	25152-Scientific editor work list.pdf