Publication Name	World Journal of Psychiatry
Manuscript ID	25243
Country	Lebanon

Received	2016-03-01 08:39
Peer-Review Started	2016-03-01 10:01
To Make the First Decision	2016-03-21 13:59
Return for Revision	2016-03-22 08:45
Revised	2016-04-16 04:25
Second Decision	2016-04-26 16:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-05-11 15:53
Articles in Press	2016-05-11 15:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-25 17:38
Publish the Manuscript Online	2016-06-19 21:16

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Linking multiple pathogenic pathways in Alzheimer’s disease
Manuscript Source	Invited Manuscript
All Author List	Rami Bou Khalil, Elie Khoury and Salam Koussa
Funding Agency and Grant Number
Corresponding Author	Rami Bou Khalil, MD, Department of Psychiatry, Hotel Dieu de France Hospital, Saint Joseph University, A. Naccache Boulevard Street, Achrafieh, PO Box 166830, Beirut, Lebanon. ramiboukhalil@hotmail.com
Key Words	Alzheimer’s disease; Etiologies; Iron; Oxidative stress; Thrombin; Vascular risk factors
Core Tip	Patients with Alzheimer’s disease (AD) have not benefited from any disease-modifying drug until now. Multiple etiologic pathways have been explored and suggest promising solutions in the future. The iron chelator deferoxamine is one potential therapeutic solution around which future studies are being directed. Another potential therapeutic solution is related to thrombin inhibitors. In this minireview, a common pathophysiological pathway is suggested for the pathogenesis of AD that is initiated by the presence of vascular risk factors inducing brain tissue hypoxia and endothelial cell activation. In predisposed individuals, this can lead to thrombin activation and iron decompartmentalization. The resulting oxidative stress will eventually lead to neuronal and glial cell death.
Publish Date	2016-06-19 21:16
Citation	Bou Khalil R, Khoury E, Koussa S. Linking multiple pathogenic pathways in Alzheimer’s disease. World J Psychiatr 2016; 6(2): 208-214
URL	http://www.wjgnet.com/2220-3206/full/v6/i2/208.htm
DOI	http://dx.doi.org/10.5498/wjp.v6.i2.208

Full Article (PDF)	WJP-6-208.pdf
Full Article (Word)	WJP-6-208.doc
Manuscript File	25243-Review.docx
Answering Reviewers	25243-Answering reviewers.pdf
Audio Core Tip	25243-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25243-Conflict-of-interest statement.pdf
Copyright License Agreement	25243-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25243-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160301020141.docx
Peer-review Report	25243-Peer-review(s).pdf
Scientific Misconduct Check	25243-Scientific misconduct check.pdf
Scientific Editor Work List	25243-Scientific editor work list.pdf