Publication Name	World Journal of Gastroenterology
Manuscript ID	25354
Country	Japan

Received	2016-03-06 19:28
Peer-Review Started	2016-03-07 11:00
To Make the First Decision	2016-04-14 09:23
Return for Revision	2016-04-15 08:34
Revised	2016-04-20 18:50
Second Decision	2016-04-25 13:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-05-04 18:11
Articles in Press	2016-05-04 18:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-26 10:30
Publish the Manuscript Online	2016-06-21 18:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Natural regression of fibrosis in chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	Shogo Ohkoshi, Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa, Kenya Kamimura and Masahiko Yano
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 25461012 (to Ohkoshi S)
Corresponding Author	Shogo Ohkoshi, MD, PhD, Department of Internal Medicine, School of Life Dentistry at Niigata, The Nippon Dental University, 1-8 Hamaura-Cho, Chuo-ku, Niigata 951-8580, Japan. okoshi@ngt.ndu.ac.jp
Key Words	Chronic hepatitis B; Cirrhosis; Spontaneous remission; Regression of fibrosis; Occult hepatitis B infection; Hepatocellular carcinoma surveillance of hepatitis B virus
Core Tip	The fibrosis of liver cirrhosis may be reversible. Regression of fibrosis in hepatitis B virus (HBV) patients with (pre)cirrhosis might be a more common phenomenon than generally considered. This might cause the underestimation of fibrosis levels in chronic hepatitis B, suggesting a difficulty with the surveillance system of HBV-hepatocellular carcinoma (HCC). That is, some HCC patients with non-cirrhotic liver might have been cirrhotic in the past, after which spontaneous regression of fibrosis occurred. Cirrhosis-HCC mechanisms, compared to the direct action of the viral genome, might be more prevalent than generally considered in HBV patients.
Publish Date	2016-06-21 18:11
Citation	Ohkoshi S, Hirono H, Watanabe K, Hasegawa K, Kamimura K, Yano M. Natural regression of fibrosis in chronic hepatitis B. World J Gastroenterol 2016; 22(24): 5459-5466
URL	http://www.wjgnet.com/1007-9327/full/v22/i24/5459.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i24.5459

Full Article (PDF)	WJG-22-5459.pdf
Full Article (Word)	WJG-22-5459.doc
Manuscript File	25354-Review.docx
Answering Reviewers	25354-Answering reviewers.pdf
Audio Core Tip	25354-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25354-Conflict-of-interest statement.pdf
Copyright License Agreement	25354-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25354-Language certificate.pdf
Peer-review Report	25354-Peer-review(s).pdf
Scientific Misconduct Check	25354-Scientific misconduct check.pdf
Scientific Editor Work List	25354-Scientific editor work list.pdf