Publication Name	World Journal of Gastroenterology
Manuscript ID	25419
Country	Ireland

Received	2016-03-09 09:35
Peer-Review Started	2016-03-09 21:30
To Make the First Decision	2016-04-14 08:44
Return for Revision	2016-04-20 14:40
Revised	2016-04-29 20:26
Second Decision	2016-05-17 10:48
Accepted by Journal Editor-in-Chief	2016-05-17 12:16
Accepted by Executive Editor-in-Chief	2016-06-02 15:36
Articles in Press	2016-06-02 15:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-23 22:24
Publish the Manuscript Online	2017-01-14 10:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Donal Tighe and Deirdre McNamara
Funding Agency and Grant Number	Funding Agency Grant Number European Crohn’s and Colitis Organisation
Corresponding Author	Dr. Donal Tighe, Department of Gastroenterology, Adelaide and Meath Incorporating the National Children's Hospital Tallaght, School of Clinical Medicine, Trinity College Dublin, Trinity Academic Gastroenterology Group, AMNCH Tallaght, Tallaght, Dublin 24, Ireland. tighedo@tcd.ie
Key Words	Inflammatory bowel disease; Ulcerative colitis; Immunomonitoring; loss of response; Anti-TNFα trough and antibody levels; Crohn's disease; immunogenicity
Core Tip	Immunomonitoring is being increasingly used to optimise response rates in inflammatory bowel disease. The aim of this review article is to explore the available literature, and to understand the rationale for using immunomonitoring and to see how this approach can be best incorporated into inflammatory bowel disease treatment algorithms. The focus of this review article is the role for immunomonitoring at the key points of induction, and at loss of response. It will emphasise the possible advantages of immunomonitoring. It will define optimal trough levels, plus targets required to achieve mucosal healing, and help alter the natural history of the disease.
Publish Date	2017-01-14 10:27
Citation	Tighe D, McNamara D. Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease. World J Gastroenterol 2017; 23(3): 414-425
URL	http://www.wjgnet.com/1007-9327/full/v23/i3/414.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i3.414

Full Article (PDF)	WJG-23-414.pdf
Full Article (Word)	WJG-23-414.doc
Manuscript File	25419-Review.docx
Answering Reviewers	25419-Answering reviewers.pdf
Audio Core Tip	25419-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25419-Conflict-of-interest statement.pdf
Copyright License Agreement	25419-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25419-Grant application form(s).pdf
Peer-review Report	25419-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25419-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25419-Scientific misconduct check.pdf
Scientific Editor Work List	25419-Scientific editor work list.pdf