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10/26/2016 3:44:00 PM | Browse: 448 | Download: 815
Publication Name World Journal of Cardiology
Manuscript ID 25460
Country/Territory United States
Received
2016-03-10 08:56
Peer-Review Started
2016-03-15 23:05
To Make the First Decision
2016-04-15 09:15
Return for Revision
2016-04-20 09:28
Revised
2016-05-28 04:53
Second Decision
2016-08-12 13:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-18 12:11
Articles in Press
2016-08-18 12:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-25 13:09
Publish the Manuscript Online
2016-10-26 15:44
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac and Cardiovascular Systems
Manuscript Type Basic Study
Article Title Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure
Manuscript Source Invited Manuscript
All Author List Tien MH Ng and Myron L Toews
Funding Agency and Grant Number
Funding Agency Grant Number
The American College of Clinical Pharmacy Research Institute
Corresponding author Tien MH Ng, Pharm.D., FHFSA, FCCP, BCPS AQ Cardiology, Associate Professor of Clinical Pharmacy and Medicine, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089-9121, United States. tienng@usc.edu
Keywords Monocytes; Cytokines; Heart failure; Inflammation
Core Tip In evaluating the relationship between sympa-thetic activation and inflammatory cytokine production in heart failure, we demonstrated that nore-pinephrine (NE) has reduced ability to suppress the production of the proinflammatory cytokine tumor necrosis factor-alpha, and increase anti-inflammatory interleukin-10, in human isolated monocytes from heart failure compared to healthy subjects. It appears to be mediated through beta-adrenergic, and not alpha-adrenergic, receptors based on monocytic THP-1 cells dose-response experiments. This suggests that the diminished immunomodulatory activity of NE in heart failure is primarily due to altered beta-adrenergic receptor function, and may represent an immunologic mechanism for the positive effects of beta-adrenergic blocking agents.
Publish Date 2016-10-26 15:44
Citation Ng TMH, Toews ML. Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure. World J Cardiol 2016; 8(10): 584-589
Url http://www.wjgnet.com/1949-8462/full/v8/i10/584.htm
DOI http://dx.doi.org/10.4330/wjc.v8.i10.584
Full Article (PDF) WJC-8-584.pdf
Full Article (Word) WJC-8-584.doc
Manuscript File 25460-Review.docx
Answering Reviewers 25460-Answering reviewers.pdf
Audio Core Tip 25460-Audio core tip.mp3
Biostatistics Review Certificate 25460-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25460-Conflict-of-interest statement.pdf
Copyright License Agreement 25460-Copyright assignment.pdf
Data Sharing Statement 25460-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25460-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160310063747.docx
Institutional Review Board Approval Form or Document 25460-Institutional review board statement.pdf
Peer-review Report 25460-Peer-review(s).pdf
Scientific Misconduct Check 25460-Scientific misconduct check.pdf
Scientific Editor Work List 25460-Scientific editor work list.pdf