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Articles Published Processes
10/26/2016 3:44:00 PM | Browse: 1231 | Download: 2440
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Received |
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2016-03-10 08:56 |
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Peer-Review Started |
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2016-03-15 23:05 |
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To Make the First Decision |
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2016-04-15 09:15 |
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Return for Revision |
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2016-04-20 09:28 |
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Revised |
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2016-05-28 04:53 |
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Second Decision |
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2016-08-12 13:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-18 12:11 |
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Articles in Press |
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2016-08-18 12:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-25 13:09 |
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Publish the Manuscript Online |
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2016-10-26 15:44 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tien MH Ng and Myron L Toews |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The American College of Clinical Pharmacy Research Institute |
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| Corresponding Author |
Tien MH Ng, Pharm.D., FHFSA, FCCP, BCPS AQ Cardiology, Associate Professor of Clinical Pharmacy and Medicine, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089-9121,
United States. tienng@usc.edu
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| Key Words |
Monocytes; Cytokines; Heart failure; Inflammation |
| Core Tip |
In evaluating the relationship between sympa-thetic activation and inflammatory cytokine production in heart failure, we demonstrated that nore-pinephrine (NE) has reduced ability to suppress the production of the proinflammatory cytokine tumor necrosis factor-alpha, and increase anti-inflammatory interleukin-10, in human isolated monocytes from heart failure compared to healthy subjects. It appears to be mediated through beta-adrenergic, and not alpha-adrenergic, receptors based on monocytic THP-1 cells dose-response experiments. This suggests that the diminished immunomodulatory activity of NE in heart failure is primarily due to altered beta-adrenergic receptor function, and may represent an immunologic mechanism for the positive effects of beta-adrenergic blocking agents.
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| Publish Date |
2016-10-26 15:44 |
| Citation |
Ng TMH, Toews ML. Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure. World J Cardiol 2016; 8(10): 584-589 |
| URL |
http://www.wjgnet.com/1949-8462/full/v8/i10/584.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v8.i10.584 |
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