Publication Name	World Journal of Transplantation
Manuscript ID	25608
Country	United States

Received	2016-03-16 11:50
Peer-Review Started	2016-03-18 18:13
To Make the First Decision	2016-05-17 13:48
Return for Revision	2016-05-19 10:34
Revised	2016-07-18 07:02
Second Decision	2016-09-05 09:31
Accepted by Journal Editor-in-Chief	2016-09-05 15:46
Accepted by Executive Editor-in-Chief	2016-09-18 14:45
Articles in Press	2016-09-18 14:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-05 14:27
Publish the Manuscript Online	2016-12-14 14:32

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Review
Article Title	Organ transplantation and drug eluting stents: Perioperative challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Aparna Dalal
Funding Agency and Grant Number
Corresponding Author	Aparna Dalal, MD, Assistant Professor, Department of Anesthesiology, Icahn School of Medicine, Mount Sinai 1428 Madison Avenue, New York, NY 10029, United States. dalalanesthesia@gmail.com
Key Words	Drug eluting stents; Cangrelor; Stent thro¬mbosis; Organ transplant; Antiplatelet medication; Platelet function assays; Mammalian target of rapamycin inhibitors; Post-transplant immunosuppression; Post-transplant endovascular inhibition; Ticagrelor; Thromboelastograms platelet mapping; Novolimus; Biolimus A9
Core Tip	Patients undergoing transplant surgery soon after the placement of drug eluting stents (DES) are at increased risk of stent thrombosis (ST) in the perioperative period. Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor is instated post stenting to decrease the incident of ST. Cadaveric organ availability is unpredictable, therefore, discontinuation of antiplatelet medication cannot be optimally timed. Many platelet function point of care tests are used to assess bleeding risk and guide perioperative platelet transfusion. Response to allogenic platelet transfusion to control severe intraoperative bleeding may differ with the antiplatelet drug. DES are now used for endovascular interventions for post-transplant orthotropic heart coronary artery disease, hepatic artery stenosis post liver transplantation, etc. Antiproliferative drugs used in DES are also used for post-transplant immunosuppression.
Publish Date	2016-12-14 14:32
Citation	Dalal A. Organ transplantation and drug eluting stents: Perio¬perative challenges. World J Transplant 2016; 6(4): 620-631
URL	http://www.wjgnet.com/2220-3230/full/v6/i4/620.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i4.620

Full Article (PDF)	WJT-6-620.pdf
Full Article (Word)	WJT-6-620.doc
Manuscript File	25608-Review.docx
Answering Reviewers	25608-Answering reviewers.pdf
Audio Core Tip	25608-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25608-Conflict-of-interest statement.pdf
Copyright License Agreement	25608-Copyright assignment.pdf
Peer-review Report	25608-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25608-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25608-Scientific misconduct check.pdf
Scientific Editor Work List	25608-Scientific editor work list.pdf