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Articles Published Processes
8/15/2016 10:30:00 AM | Browse: 1046 | Download: 2492
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Received |
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2016-03-17 10:38 |
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Peer-Review Started |
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2016-03-18 18:46 |
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To Make the First Decision |
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2016-05-12 09:14 |
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Return for Revision |
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2016-05-16 15:33 |
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Revised |
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2016-05-26 19:38 |
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Second Decision |
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2016-05-31 15:21 |
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Accepted by Journal Editor-in-Chief |
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2016-06-02 03:32 |
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Accepted by Executive Editor-in-Chief |
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2016-06-13 17:47 |
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Articles in Press |
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2016-06-13 17:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-07-18 16:42 |
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Typeset the Manuscript |
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2016-08-04 09:06 |
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Publish the Manuscript Online |
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2016-08-15 10:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Development of a human rotavirus induced diarrhea model in Chinese mini-pigs
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Tao Li, Jing Wei, Hong-Xia Guo, Jiang-Bo Han, Nan Ye, Hai-Yang He, Tian-Tian Yu and Yu-Zhang Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
30400402 |
| Natural Science Foundation of China |
30571708 |
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| Corresponding Author |
Jin-tao Li, PhD, professor, Institute of Tropical Medicine, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, China. ljtqms@qq.com |
| Key Words |
human rotavirus; animal model; Chinese mini-pigs; diarrhea; intestine |
| Core Tip |
rotavirus (RV) is the leading cause of serious dehydrating diarrhea in infants and young children worldwide. Animal models for RV infection research have provided key insights into the RV infection, its pathogenesis and immunity, and have offered opportunities for design and evaluation of potential vaccines. Our study indicated that human RV (HRV) could effectively replicate in the intestinal villi of the ileum of Chinese mini-pigs and lead to histopathological alterations and diarrhea. This research offers a new animal model for studying the pathological changes and immunogenicity of HRV infection and a useful tool in the design and evaluation of RV vaccines. |
| Publish Date |
2016-08-15 10:30 |
| Citation |
Li JT, Wei J, Guo HX, Han JB, Ye N, He HY, Yu TT, Wu YZ. Development of a human rotavirus induced diarrhea model in Chinese mini-pigs. World J Gastroenterol 2016; 22(31): 7135-7145 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i31/7135.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i31.7135 |
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