Publication Name	World Journal of Hepatology
Manuscript ID	25688
Country	Canada

Received	2016-03-20 17:27
Peer-Review Started	2016-03-22 14:39
To Make the First Decision	2016-05-17 13:50
Return for Revision	2016-05-19 11:00
Revised	2016-05-25 22:16
Second Decision	2016-07-07 08:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-07-18 11:09
Articles in Press	2016-07-18 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-30 18:13
Publish the Manuscript Online	2016-08-17 08:44

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training
Manuscript Source	Invited Manuscript
All Author List	Jean-Marc Lavoie
Funding Agency and Grant Number	Funding Agency Grant Number Natural Sciences and Engineering Research Council of Canada NSERC 7594
Corresponding Author	Jean-Marc Lavoie, PhD, Professor, De­partment of Kinesiology, University of Montreal, CP 6128, Succ “Centre-ville”, Montreal, Québec H3C 3J7, Canada. jean-marc.lavoie@umontreal.ca
Key Words	PSCK9; Low-density lipoprotein receptor; Very low-density lipoprotein; Sterol regulatory element binding proteins; Ovariectomy; High-density lipoprotein; Lipoproteins
Core Tip	The liver is considered the master piece in regulation of plasma cholesterol levels. Together with the intestine they control the influx and the efflux of cholesterol and biliary acids in the body. Cholesterol and its conversion into biliary acids are regulated by an extended network of enzymes and transporters that largely influence plasma cholesterol levels. The key regulators of cholesterol and biliary acids in liver and intestine are in turn affected by several factors including estrogens levels and more recently exercise training. Low estrogenic levels, such as seen in post-menopausal women, are associated with higher plasma cholesterol levels. In recent years more information has been accumulated on the extent to which low estrogenic levels, such as seen in an ovariectomized animal model, influence cholesterol and biliary metabolism at the molecular level. As an alternative to a deficiency in estro-gens, exercise training has been reported to exert a beneficial effect on these key regulators of cholesterol and biliary acids.
Publish Date	2016-08-17 08:44
Citation	Lavoie JM. Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training. World J Hepatol 2016; 8(23): 961-975
URL	http://www.wjgnet.com/1948-5182/full/v8/i23/961.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i23.961

Full Article (PDF)	WJH-8-961.pdf
Full Article (Word)	WJH-8-961.doc
Manuscript File	25688-Review.docx
Answering Reviewers	25688-Answering reviewers.pdf
Audio Core Tip	25688-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25688-Conflict-of-interest statement.pdf
Copyright License Agreement	25688-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25688-Grant application form(s).pdf
Peer-review Report	25688-Peer-review(s).pdf
Scientific Misconduct Check	25688-Scientific misconduct check.pdf
Scientific Editor Work List	25688-Scientific editor work list.pdf