Publication Name	World Journal of Stem Cells
Manuscript ID	25693
Country	India

Received	2016-03-20 17:07
Peer-Review Started	2016-03-22 14:51
To Make the First Decision	2016-04-15 08:24
Return for Revision	2016-04-20 09:50
Revised	2016-04-25 00:00
Second Decision	2016-06-12 10:16
Accepted by Journal Editor-in-Chief	2016-06-13 17:01
Accepted by Executive Editor-in-Chief	2016-06-29 10:15
Articles in Press	2016-06-29 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-11 11:15
Typeset the Manuscript	2016-08-11 15:39
Publish the Manuscript Online	2016-08-19 16:02

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges
Manuscript Source	Invited Manuscript
All Author List	Minal Garg
Funding Agency and Grant Number	Funding Agency Grant Number Department of Science and Technology, Govt. of India SR/H0/HS/0113-2010
Corresponding Author	Minal Garg, Msc, PhD, Assistant Professor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com
Key Words	Cancer stem cells; Clinical management; Cytotoxic effects; Epithelial plasticity; Therapeutic resistance; Urothelial carcinoma; Urothelial stem cells
Core Tip	A subset of bladder cancer cells, known as urothelial cancer stem cells, have abilities to self-renew, generate tumor heterogeneity via differentiation, and are actually responsible for tumor relapse and metastasis formation. Delineating the mechanistic complexity between epithelial plasticity and cancer stemness in malignant transformation of urothelial carcinoma provides the basis for designing rational therapies. Differentiation and elimination therapies targeting the potential biomarkers could prove to be clinically beneficial by suppressing the cancer stemness and inhibiting epithelial-to-mesen-chymal transition phenotype and would provide novel opportunities for targeted therapeutic approaches in the clinical management of patients.
Publish Date	2016-08-19 16:02
Citation	Garg M. Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges. World J Stem Cells 2016; 8(8): 260-267
URL	http://www.wjgnet.com/1948-0210/full/v8/i8/260.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i8.260

Full Article (PDF)	WJSC-8-260.pdf
Full Article (Word)	WJSC-8-260.doc
Manuscript File	25693-Review.docx
Answering Reviewers	25693-Answering reviewers.pdf
Audio Core Tip	25693-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25693-Conflict-of-interest statement.pdf
Copyright License Agreement	25693-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25693-Grant application form(s).pdf
Peer-review Report	25693-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25693-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25693-Scientific misconduct check.pdf
Scientific Editor Work List	25693-Scientific editor work list.pdf