Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	25696
Country	United States

Received	2016-03-20 16:59
Peer-Review Started	2016-03-22 15:01
First Decision by Editorial Office Director
Return for Revision	2016-04-20 10:04
Revised	2016-05-03 02:16
Publication Fee Transferred
Second Decision by Editor	2016-06-27 17:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-07-13 14:10
Articles in Press	2016-07-13 14:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-01 16:00
Publish the Manuscript Online	2016-08-07 21:31

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children
Manuscript Source	Invited Manuscript
All Author List	Arzu Ari
Funding Agency and Grant Number
Corresponding Author	Arzu Ari, FAARC, PhD, PT, RRT, Department of Respiratory Therapy, Georgia State University, 140 Decatur Street Suite 1228, Atlanta, GA 30303-3083, United States. arzuari@hotmail.com
Key Words	Aerosols; Inhalation therapy; Children; Masks; Mouthpiece; High flow nasal cannula; Blow-by; Hood; Spacer/valved holding chamber
Core Tip	Many interfaces exist for aerosol drug delivery to spontaneously breathing children and inhala-tion therapy with different interfaces has become an impor-tant topic of interest among clinicians. However, clini-cians usually focus on selecting the right drug-device combination and often overlook the importance of interface selection that lead to suboptimal drug delivery and therapeutic response in neonates and pediatrics. This paper provides a critical assessment of drug delivery interfaces used for the treatment of children with pulmonary diseases by emphasizing advantages and problems associated with their use during inhalation therapy.
Publish Date	2016-08-07 21:31
Citation	Ari A. Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children. World J Clin Pediatr 2016; 5(3): 281-287
URL	http://www.wjgnet.com/2219-2808/full/v5/i3/281.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i3.281

Full Article (PDF)	WJCP-5-281.pdf
Full Article (Word)	WJCP-5-281.doc
Manuscript File	25696-Review.docx
Answering Reviewers	25696-Answering reviewers.pdf
Audio Core Tip	25696-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25696-Conflict-of-interest statement.pdf
Copyright License Agreement	25696-Copyright assignment.pdf
Peer-review Report	25696-Peer-review(s).pdf
Scientific Misconduct Check	25696-Scientific misconduct check.pdf
Scientific Editor Work List	25696-Scientific editor work list.pdf