Publication Name	World Journal of Hepatology
Manuscript ID	25877
Country	France

Received	2016-04-02 10:25
Peer-Review Started	2016-04-06 14:27
To Make the First Decision	2016-05-16 10:50
Return for Revision	2016-05-16 16:59
Revised	2016-05-29 00:00
Second Decision	2016-06-12 10:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-29 09:42
Articles in Press	2016-06-29 09:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-14 18:55
Publish the Manuscript Online	2016-07-22 10:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Basic Study
Article Title	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model
Manuscript Source	Invited Manuscript
All Author List	Sylvie Lagaye, Sonia Brun, Jesintha Gaston, Hong Shen, Ruzena Stranska, Claire Camus, Clarisse Dubray, Géraldine Rousseau, Pierre-Philippe Massault, Jerôme Courcambeck, Firas Bassisi, Philippe Halfon and Stanislas Pol
Funding Agency and Grant Number	Funding Agency Grant Number Institut National de la Santé et de la Recherche Médicale (INSERM, France) personal support of Professor Jean-François Delfraissy as Director of the French Agency, Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS)
Corresponding Author	Sylvie Lagaye, PhD, DSc, Senior Scientist, Institut Pasteur, INSERM U1223, 25-28 rue du Dr Roux, 75015 Paris, France. sylvie.lagaye@inserm.fr
Key Words	Host antiviral therapy; Hepatitis C virus; Tissue culture; Autophagy; Quinoline derivative
Core Tip	Hepatitis C virus (HCV) infection (or spread) is a serious public health challenge counting approximately 170 million people that are chronically infected world-wide. Efficient interferon-free treatments with new direct acting antivirals are expected to cure more than 90% of HCV-infected patients but they are not available in all the countries. Autophagy machinery is required to initiate HCV replication. Host antiviral therapy is an additional option for the treatment of HCV infection. The new autophagy inhibitor GNS-396 demonstrated significant efficacy and additive activity in inhibiting HCV replication and might be an additional option to treat HCV infected individuals.
Publish Date	2016-07-22 10:22
Citation	Lagaye S, Brun S, Gaston J, Shen H, Stranska R, Camus C, Dubray C, Rousseau G, Massault PP, Courcambeck J, Bassisi F, Halfon P, Pol S. Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model. World J Hepatol 2016; 8(21): 902-914
URL	http://www.wjgnet.com/1948-5182/full/v8/i21/902.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i21.902

Full Article (PDF)	WJH-8-902.pdf
Full Article (Word)	WJH-8-902.doc
Manuscript File	25877-Review.doc
Answering Reviewers	25877-Answering reviewers.pdf
Audio Core Tip	25877-Audio core tip.m4a
Biostatistics Review Certificate	25877-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20160401180335.docx
Conflict-of-Interest Disclosure Form	25877-Conflict-of-interest statement.pdf
Copyright License Agreement	25877-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25877-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160401180733.docx
Institutional Animal Care and Use Committee Approval Form or Document	25877-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	25877-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25877-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160401181355.docx
Peer-review Report	25877-Peer-review(s).pdf
Scientific Misconduct Check	25877-Scientific misconduct check.pdf
Scientific Editor Work List	25877-Scientific editor work list.pdf