Publication Name	World Journal of Gastroenterology
Manuscript ID	25986
Country	China

Received	2016-03-28 15:48
Peer-Review Started	2016-03-28 16:57
To Make the First Decision	2016-05-12 14:29
Return for Revision	2016-05-13 09:00
Revised	2016-05-21 18:38
Second Decision	2016-06-06 08:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-15 19:02
Articles in Press	2016-06-15 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-06-27 14:51
Typeset the Manuscript	2016-08-05 14:07
Publish the Manuscript Online	2016-08-15 10:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Current understanding concerning intestinal stem cells
Manuscript Source	Invited Manuscript
All Author List	Shuang Cui and Peng-Yu Chang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81502751 National Natural Science Foundation of China 81372929
Corresponding Author	Peng-Yu Chang, MD, Department of Radiation Oncology, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province, China. edvence@163.com
Key Words	Intestinal stem cell; Cell development; Colorectal cancer
Core Tip	Although the specific roles of intestinal stem cells in epithelial homeostasis and regeneration have been explored, the specific markers for identifying intestinal stem cells (ISCs) remain unclear. The reserve pool of intestinal stem cells is located at the 4+ position of crypts, and their biological characteristics are distinct from the intestinal stem cells at the crypt basement membrane. Intestinal stem cells are important cellular sources for initiating colorectal cancers. Managing murine models of ulcerous colitis using colon organoids indicates the therapeutic effects of ISCs.
Publish Date	2016-08-15 10:30
Citation	Cui S, Chang PY. Current understanding concerning intestinal stem cells. World J Gastroenterol 2016; 22(31): 7099-7110
URL	http://www.wjgnet.com/1007-9327/full/v22/i31/7099.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i31.7099

Full Article (PDF)	WJG-22-7099.pdf
Full Article (Word)	WJG-22-7099.doc
Manuscript File	25986-Review.docx
Answering Reviewers	25986-Answering reviewers.pdf
Audio Core Tip	25986-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25986-Conflict-of-interest statement.pdf
Copyright License Agreement	25986-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25986-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	25986-Language certificate.pdf
Peer-review Report	25986-Peer-review(s).pdf
Scientific Misconduct Check	25986-Scientific misconduct check.pdf
Scientific Editor Work List	25986-Scientific editor work list.pdf