Publication Name	World Journal of Gastroenterology
Manuscript ID	26025
Country	India

Received	2016-03-28 13:41
Peer-Review Started	2016-03-28 14:16
To Make the First Decision	2016-05-12 14:25
Return for Revision	2016-05-13 09:07
Revised	2016-05-30 00:26
Second Decision	2016-06-06 08:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-06-15 19:05
Articles in Press	2016-06-15 19:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-27 16:00
Publish the Manuscript Online	2016-07-04 14:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Review
Article Title	Gut dysfunction in Parkinson's disease
Manuscript Source	Invited Manuscript
All Author List	Adreesh Mukherjee, Atanu Biswas and Shyamal Kumar Das
Funding Agency and Grant Number
Corresponding Author	Shyamal Kumar Das, MD, DM, Professor, Head, Department of Neurology, Bangur Institute of Neurosciences and Institute of Post Graduate Medical Education and Research, 52/1A Sambhu Nath Pandit Street, Kolkata, West Bengal 700025, India. das_sk70@hotmail.com
Key Words	Parkinson’s disease; Gut dysfunction; Sialorrhea; Dysphagia; Gastroparesis; Constipation; Gut microbiota
Core Tip	Gut is involved in early Parkinson’s disease (PD) with extensive synuclein pathology, following a rostrocaudal gradient along the gastrointestinal system. It may act as the starting point of PD pathology with prion-like spread toward the central nervous system. The clinical manifestations include malnutrition, oral and dental disorders, sialorrhea, dysphagia, gastroparesis, constipation, and defecatory dysfunction. These are distressing for the patients and need to be managed properly by pharmacological or non-pharmacological measures. Gut dysfunction also leads to response fluctuations in PD and this may require alternative routes of administration or drug delivery systems for anti-PD medications.
Publish Date	2016-07-04 14:42
Citation	Mukherjee A, Biswas A, Das SK. Gut dysfunction in parkinson’s disease. World J Gastroenterol 2016; 22(25): 5742-5752
URL	http://www.wjgnet.com/1007-9327/full/v22/i25/5742.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i25.5742

Full Article (PDF)	WJG-22-5742.pdf
Full Article (Word)	WJG-22-5742.doc
Manuscript File	26025-Review.docx
Answering Reviewers	26025-Answering reviewers.pdf
Audio Core Tip	26025-Audio core tip.wav
Conflict-of-Interest Disclosure Form	26025-Conflict-of-interest statement.pdf
Copyright License Agreement	26025-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26025-Language certificate.pdf
Peer-review Report	26025-Peer-review(s).pdf
Scientific Misconduct Check	26025-Scientific misconduct check.pdf
Scientific Editor Work List	26025-Scientific editor work list.pdf