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Articles Published Processes
8/9/2016 8:46:00 AM | Browse: 997 | Download: 1475
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Received |
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2016-03-28 09:02 |
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Peer-Review Started |
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2016-03-28 15:55 |
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To Make the First Decision |
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2016-05-16 10:51 |
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Return for Revision |
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2016-05-16 17:05 |
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Revised |
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2016-05-24 09:35 |
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Second Decision |
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2016-05-27 17:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-06-03 16:26 |
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Articles in Press |
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2016-06-03 16:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-25 09:03 |
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Publish the Manuscript Online |
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2016-08-09 08:50 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vivian Weiss, Julie Dueber, Jesse P Wright, Justin Cates, Frank Revetta, Alexander A Parikh, Nipun B Merchant and Chanjuan Shi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Chanjuan Shi, MD, PhD, Associate Professor, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North C-2310D, 1121 21st Ave. S, Nashville, TN 37232, United States. chanjuan.shi@vanderbilt.edu |
| Key Words |
β-catenin; Familial adenomatous polyposis; Pancreatic neuroendocrine neoplasm; Adenomatous polyposis coli; E-cadherin |
| Core Tip |
Dysregulation of the Wnt/β-catenin pathway is present in some pancreatic neuroendocrine neoplasms (PanNENs). However, compared to other malignancies, this signaling pathway may have different functions in PanNENs as strong membranous β-catenin expression is more frequently present in stage Ⅲ/Ⅳ tumors and membranous expression of β-catenin and E-cadherin does not have a prognostic importance in this setting. Additionally, PanNENs arising in patients with familial adenomatous polyposis (FAP) demonstrate abnormal nuclear β-catenin accumulation, and PanNENs may be one of the extraintestinal manifestations of FAP. |
| Publish Date |
2016-08-09 08:50 |
| Citation |
Weiss V, Dueber J, Wright JP, Cates J, Revetta F, Parikh AA, Merchant NB, Shi C. Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms. World J Gastrointest Oncol 2016; 8(8): 615-622 |
| URL |
http://www.wjgnet.com/1948-5204/full/v8/i8/615.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v8.i8.615 |
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