Publication Name	World Journal of Gastroenterology
Manuscript ID	26063
Country	Egypt

Received	2016-03-28 09:58
Peer-Review Started	2016-03-31 08:54
To Make the First Decision	2016-05-12 15:31
Return for Revision	2016-05-13 15:17
Revised	2016-06-11 21:24
Second Decision	2016-06-23 17:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-07-06 18:40
Articles in Press	2016-07-06 18:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-30 10:45
Publish the Manuscript Online	2016-08-04 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms
Manuscript Source	Invited Manuscript
All Author List	Mahmoud Fathy Dondeti, Eman Anwar El-Maadawy and Roba Mohamed Talaat
Funding Agency and Grant Number
Corresponding Author	Dr. Roba Mohamed Talaat, Assiatant Professor, Molecular Immunology, Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City 21547, Egypt. roba.talaat@gebri.usc.edu.eg
Key Words	Hepatocellular carcinoma; Hepatitis C virus; Hepatitis B virus; Cytokines; Polymorphism
Core Tip	Cytokines have a decisive role in the pathophysiology of many infectious, autoimmune and malig-nant diseases. Changes in cytokine secretion profile are involved in one way or another in susceptibility to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and eventualy are thought to influence the disease phenotype and the rapid progression to HCC. Individual variation in cytokine profile might, at least partially, to genetic alteration within the regulatory regions of cytokine genes. One of the most studied phenomena is the allelic polymorphism and its implication in cytokine gene expression, and the susceptibility to infection, clinical severity of diseases and response to treatment. This review concentrates on the cytokine gene polymorphism case-control and meta-analysis studies performed all over the world on hepatocellular carcinoma patients (as a consequence to HBV or HCV infection).
Publish Date	2016-08-04 17:58
Citation	Dondeti MF, El-Maadawy EA, Talaat RM. Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms. World J Gastroenterol 2016; 22(30): 6800-6816
URL	http://www.wjgnet.com/1007-9327/full/v22/i30/6800.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i30.6800

Full Article (PDF)	WJG-22-6800.pdf
Full Article (Word)	WJG-22-6800.doc
Manuscript File	26063-Review.docx
Answering Reviewers	26063-Answering reviewers.pdf
Audio Core Tip	26063-Audio core tip.mp3
Copyright License Agreement	26063-Copyright assignment.pdf
Peer-review Report	26063-Peer-review(s).pdf
Scientific Misconduct Check	26063-Scientific misconduct check.pdf
Scientific Editor Work List	26063-Scientific editor work list.pdf