Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	26102
Country	Japan

Received	2016-03-29 09:26
Peer-Review Started	2016-04-01 13:07
To Make the First Decision	2016-05-23 10:01
Return for Revision	2016-05-25 19:17
Revised	2016-07-19 21:45
Second Decision	2016-09-05 09:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-09-18 14:19
Articles in Press	2016-09-18 14:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-07 20:29
Publish the Manuscript Online	2016-11-14 09:26

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Takahiro Tsuchikawa, Shintaro Takeuchi, Toru Nakamura, Toshiaki Shichinohe and Satoshi Hirano
Funding Agency and Grant Number
Corresponding Author	Dr. Takahiro Tsuchikawa, Associate Professor, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, N-15 W-7, Sapporo 060-8638, Japan. tsuchi-t@med.hokudai.ac.jp
Key Words	Pancreas cancer; Microenvironment; Chemo­therapy; Immune cells; Immunomodulation
Core Tip	It has been gradually clear that the chemo-therapeutic agents are two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment including infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts could be improved. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal treatment strategy.
Publish Date	2016-11-14 09:26
Citation	Tsuchikawa T, Takeuchi S, Nakamura T, Shichinohe T, Hirano S. Clinical impact of chemotherapy to improve tumor micro­environment of pancreatic cancer. World J Gastrointest Oncol 2016; 8(11): 786-792
URL	http://www.wjgnet.com/1948-5204/full/v8/i11/786.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i11.786

Full Article (PDF)	WJGO-8-786.pdf
Full Article (Word)	WJGO-8-786.doc
Manuscript File	26102-Review.docx
Answering Reviewers	26102-Answering reviewers.pdf
Audio Core Tip	26102-Audio core tip.wav
Conflict-of-Interest Disclosure Form	26102-Conflict-of-interest statement.pdf
Copyright License Agreement	26102-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26102-Language certificate.pdf
Peer-review Report	26102-Peer-review(s).pdf
Scientific Misconduct Check	26102-Scientific misconduct check.pdf
Scientific Editor Work List	26102-Scientific editor work list.pdf