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9/23/2016 3:41:00 PM | Browse: 659 | Download: 507
Publication Name World Journal of Transplantation
Manuscript ID 26201
Country/Territory Germany
2016-03-30 09:07
Peer-Review Started
2016-03-31 10:55
To Make the First Decision
2016-05-16 10:57
Return for Revision
2016-05-17 16:19
2016-06-24 14:28
Second Decision
2016-07-05 17:38
Accepted by Journal Editor-in-Chief
2016-07-05 23:52
Accepted by Company Editor-in-Chief
2016-07-18 10:42
Articles in Press
2016-07-18 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-19 10:13
Publish the Manuscript Online
2016-09-23 15:41
ISSN 2220-3230 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Basic Study
Article Title Pharmacological Tie2 activation in kidney transplantation
Manuscript Source Invited Manuscript
All Author List Kristina Thamm, Florence Njau, Paul Van Slyke, Daniel J Dumont, Joon-Keun Park, Hermann Haller and Sascha David
Funding Agency and Grant Number
Funding Agency Grant Number
Else-Kröner Fresenius Stiftung 2013_A154
German Research Foundation DA 1209/4-1 (to David S)
Corresponding author Sascha David, MD, Department of Nephrology and Hypertension, Medical School Hannover, Carl Neuberg-Straße 1, 30625 Hannover, Germany. david.sascha@mh-hannover.de
Keywords Vasculotide; Tie2; Kidney transplantation; Endothelium; Angiopoietin
Core Tip Activation of the Tie2 receptor has been shown to be beneficial in different models of disease. Here, we demonstrate that agonistic stimulation of Tie2 via the drug-like putative therapeutic termed “vasculotide” (VT) ameliorates outcome in a murine MHC-mismatched kidney transplant model. VT treatment (i.e., activation of endothelial Tie2) prevented inflammation and fibrosis thereby preserving graft function. Moreover, single administration at the time of transplantation was also sufficient to prolong survival compared to control group.
Publish Date 2016-09-23 15:41
Citation Thamm K, Njau F, Van Slyke P, Dumont DJ, Park JK, Haller H, David S. Pharmacological Tie2 activation in kidney transplantation. World J Transplant 2016; 6(3): 573-582
Url http://www.wjgnet.com/2220-3230/full/v6/i3/573.htm
DOI http://dx.doi.org/10.5500/wjt.v6.i3.573
Full Article (PDF) WJT-6-573.pdf
Full Article (Word) WJT-6-573.doc
Manuscript File 26201-Review.docx
Answering Reviewers 26201-Answering reviewers.pdf
Audio Core Tip 26201-Audio core tip.mp3
Biostatistics Review Certificate 26201-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 26201-Conflict-of-interest statement.pdf
Copyright License Agreement 26201-Copyright assignment.pdf
Data Sharing Statement 26201-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 26201-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 26201-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 26201-Institutional review board statement.pdf
Peer-review Report 26201-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 26201-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 26201-Scientific misconduct check.pdf
Scientific Editor Work List 26201-Scientific editor work list.pdf