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Articles Published Processes
7/29/2016 8:32:00 PM | Browse: 930 | Download: 2322
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Received |
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2016-04-01 10:16 |
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Peer-Review Started |
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2016-04-06 17:22 |
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To Make the First Decision |
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2016-05-30 09:21 |
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Return for Revision |
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2016-05-30 14:30 |
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Revised |
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2016-06-08 13:13 |
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Second Decision |
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2016-06-14 17:58 |
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Accepted by Journal Editor-in-Chief |
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2016-06-14 18:40 |
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Accepted by Executive Editor-in-Chief |
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2016-06-29 09:41 |
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Articles in Press |
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2016-06-29 09:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-18 15:45 |
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Publish the Manuscript Online |
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2016-07-29 20:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jeongeun Hyun and Youngmi Jung |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea funded by the Korean Government (MEST) |
2013R1A2A2A01068268 (to Jung Y) |
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| Corresponding Author |
Youngmi Jung, PhD, Department of Biological Sciences, College of Natural Science, Pusan National University, Pusandaehak-ro 63beon-gil, Geumjeong-gu, Pusan 46241, South Korea. y.jung@pusan.ac.kr
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| Key Words |
MicroRNA; Liver fibrosis; Hedgehog; Hepatic stellate cell |
| Core Tip |
MicroRNAs (miRNAs) influence various biological responses by controlling gene expression. Recent studies investigate the roles of miRNAs in liver fibrosis, due to their potential as biomarkers and therapeutic agents. Hedgehog (Hh) signaling contributes to hepatic fibrosis. Hence, regulation of Hh signaling is one of the therapeutic strategies against liver fibrogenesis. Therefore, we introduce miRNAs relevant to Hh signaling and discuss the interaction of miRNAs with Hh signaling, with a particular focus on the anti-fibrotic effect of Hh-regulating miRNAs in liver diseases. This review suggests that miRNAs-mediating Hh signaling are the novel diagnostic and therapeutic targets for treating liver disease.
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| Publish Date |
2016-07-29 20:32 |
| Citation |
Hyun J, Jung Y. MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling. World J Gastroenterol 2016; 22(29): 6652-6662 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i29/6652.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i29.6652 |
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