| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Takafumi Saito, Masahiro Sugimoto, Kazuo Okumoto, Hiroaki Haga, Tomohiro Katsumi, Kei Mizuno, Taketo Nishina, Sonoko Sato, Kaori Igarashi, Hiroko Maki, Masaru Tomita, Yoshiyuki Ueno and Tomoyoshi Soga |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Agency for Medical Research and Development |
|
| Yamagata Prefectural Government and City of Tsuruoka |
|
|
| Corresponding Author |
Takafumi Saito, MD, Associate Professor of Gastroenterology, Department of Gastroenterology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata, Yamagata 990-9585, Japan. tasaitoh@med.id.yamagata-u.ac.jp
|
| Key Words |
Metabolome; Hepatocellular carcinoma; γ-glutamyl peptides; Glutathione; Oxidative stress |
| Core Tip |
Serum metabolome analysis was applied to the patients of hepatocellular carcinoma (HCC) infected with hepatitis B virus (HBV) or hepatitis C virus (HCV) to clarify the characteristics of their metabolite profiles. This study demonstrated that the serum concentrations of γ-glutamyl peptides and their concentration patterns contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between the HCC patients infected with HBV and HCV may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.
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| Publish Date |
2016-07-15 15:38 |
| Citation |
Saito T, Sugimoto M, Okumoto K, Haga H, Katsumi T, Mizuno K, Nishina T, Sato S, Igarashi K, Maki H, Tomita M, Ueno Y, Soga T. Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C. World J Gastroenterol 2016; 22(27): 6224-6234 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i27/6224.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i27.6224 |
