Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	26301
Country	India

Received	2016-04-02 18:14
Peer-Review Started	2016-04-07 15:22
To Make the First Decision	2016-06-06 17:23
Return for Revision	2016-06-07 14:28
Revised	2016-07-11 18:39
Second Decision	2016-07-27 15:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-09-18 14:33
Articles in Press	2016-09-18 14:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-28 18:17
Publish the Manuscript Online	2016-12-06 18:50

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Signet ring colorectal carcinoma: Do we need to improve the treatment algorithm?
Manuscript Source	Invited Manuscript
All Author List	Anup Sunil Tamhankar, Parag Ingle, Reena Engineer, Munita Bal, Vikas Ostwal and Avanish Saklani
Funding Agency and Grant Number
Corresponding Author	Dr. Avanish Saklani, MS, FRCS, Associate Professor, Department of Gastro-Intestinal Surgery, Tata Memorial Centre, Mumbai, Maharashtra 400012, India. asaklani@hotmail.com
Key Words	Colorectal cancer; Signet ring cell car­cinoma; Peritoneal metastases; Hyperthermic intra-peritoneal chemotherapy
Core Tip	The incidence of Signet Ring Colo-Rectal Cancer appears to be higher in Indian subcontinent than the world literature. It has predilection for peritoneal lining. It affects younger age group. Majority cases present in stage III and IV. Recto-sigmoid region is affected commonly. The most common metastatic site and site of recurrence is peritoneal cavity. Probably it should be treated with a different protocol than the conventional adenocarcinoma with focus on aggressive peritoneal cytoreductions and hyperthermic intra-operative intraperitoneal chemotherapy (HIPEC). Further research is needed to evaluate molecular biology of this variant and utility of prophylactic HIPEC during curative surgery.
Publish Date	2016-12-06 18:50
Citation	Tamhankar AS, Ingle P, Engineer R, Bal M, Ostwal V, Saklani A. Signet ring colorectal carcinoma: Do we need to improve the treatment algorithm? World J Gastrointest Oncol 2016; 8(12): 819-825
URL	http://www.wjgnet.com/1948-5204/full/v8/i12/819.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i12.819

Full Article (PDF)	WJGO-8-819.pdf
Full Article (Word)	WJGO-8-819.doc
Manuscript File	26301-Review.docx
Answering Reviewers	26301-Answering reviewers.pdf
Audio Core Tip	26301-Audio core tip.wav
Biostatistics Review Certificate	26301-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	26301-Conflict-of-interest statement.pdf
Copyright License Agreement	26301-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	26301-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	26301-Language certificate.pdf
Peer-review Report	26301-Peer-review(s).pdf
Scientific Misconduct Check	26301-Scientific misconduct check.pdf
Scientific Editor Work List	26301-Scientific editor work list.pdf