Publication Name	World Journal of Gastroenterology
Manuscript ID	26342
Country	Germany

Received	2016-04-05 09:40
Peer-Review Started	2016-04-05 14:16
To Make the First Decision	2016-05-12 10:27
Return for Revision	2016-05-12 10:54
Revised	2016-05-25 17:41
Second Decision	2016-06-02 10:15
Accepted by Journal Editor-in-Chief	2016-06-04 12:45
Accepted by Executive Editor-in-Chief	2016-06-13 18:10
Articles in Press	2016-06-13 18:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-14 14:21
Publish the Manuscript Online	2016-07-22 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases
Manuscript Source	Invited Manuscript
All Author List	Nathalie Britzen-Laurent, Christian Herrmann, Elisabeth Naschberger, Roland S Croner and Michael Stürzl
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation DFG-KFO257 German Research Foundation SFB796 German Research Foundation DFG-BR5196 Interdisciplinary Center for Clinical Research (IZKF) of the Clinical Center Erlangen
Corresponding Author	Dr. Michael Stürzl, Professor, Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Translational Research Center, Friedrich-Alexander University of Erlangen-Nuremberg, Schwabachanlage 12, 91054 Erlangen, Germany. michael.stuerzl@uk-erlangen.de
Key Words	Guanylate-binding proteins; Colorectal carcinoma; Inflammatory bowel diseases; Interferon
Core Tip	Guanylate-binding proteins (GBPs) are interferon-stimulated factors involved in the defense against cellular pathogens and inflammation. In addition, guanylate-binding proteins have been established as reliable markers of interferon-gamma-activated cells in various diseases including colorectal carcinoma and inflammatory bowel diseases. The GBP-1 is the best characterized member of the family. For instance, the expression of GBP-1 has been associated with a better outcome in colorectal carcinoma. The inhibition of tumor growth by GBP-1 is due to its strong anti-angiogenic activity as well as its direct anti-tumorigenic effect on tumor cells. In inflammatory bowel diseases, on the one hand GBP-1 mediates the anti-proliferative effects of interferon-gamma on intestinal epithelial cells, and on the other hand, it protects the mucosa by preventing cell apoptosis, by inhibiting angiogenesis and by regulating the T-cell receptor signaling. These functions rely to a large extent on the ability of GBP-1 to interact with and remodel the actin cytoskeleton.
Publish Date	2016-07-22 13:48
Citation	Britzen-Laurent N, Herrmann C, Naschberger E, Croner RS, Stürzl M. Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases. World J Gastroenterol 2016; 22(28): 6434-6443
URL	http://www.wjgnet.com/1007-9327/full/v22/i28/6434.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i28.6434

Full Article (PDF)	WJG-22-6434.pdf
Full Article (Word)	WJG-22-6434.doc
Manuscript File	26342-Review.docx
Answering Reviewers	26342-Answering reviewers.pdf
Audio Core Tip	26342-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26342-Conflict-of-interests statement.pdf
Copyright License Agreement	26342-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26342-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	26342-Language certificate.pdf
Peer-review Report	26342-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26342-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26342-Scientific misconduct check.pdf
Scientific Editor Work List	26342-Scientific editor work list.pdf