Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26347
Country	Japan

Received	2016-04-05 09:16
Peer-Review Started	2016-04-05 14:27
To Make the First Decision	2016-06-06 17:26
Return for Revision	2016-06-07 14:21
Revised	2016-06-19 10:18
Second Decision	2016-07-12 13:02
Accepted by Journal Editor-in-Chief	2016-07-13 22:43
Accepted by Executive Editor-in-Chief	2016-07-22 12:14
Articles in Press	2016-07-22 12:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-25 09:02
Publish the Manuscript Online	2016-08-01 11:49

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Infertility in men with inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Takeshi Shin and Hiroshi Okada
Funding Agency and Grant Number
Corresponding Author	Takeshi Shin, MD, Assistant Professor, Department of Urology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan. shintakeshi@nifty.com
Key Words	Crohn’s disease; Infertility; Inflammatory bowel disease; Male; Ulcerative colitis
Core Tip	In men with inflammatory bowel disease (IBD), factors such as surgery, medications, disease activity, and poor nutritional status are thought to contribute to infertility. Surgery with rectal incision is associated with sexual dysfunction (e.g., erectile dysfunction, anejaculation, and retrograde ejaculation). Among medications, sulfasalazine causes reversible qualitative and quantitative semen abnormalities. No other medications seem to affect male fertility significantly. There are limited data on the effects of paternal exposure to IBD medications on pregnancy outcomes, but no significant increase in fetal risk has been noted except for thiopurines. Patients should be appropriately informed of possible effects of paternal drug exposure.
Publish Date	2016-08-01 11:49
Citation	Shin T, Okada H. Infertility in men with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2016; 7(3): 361-369
URL	http://www.wjgnet.com/2150-5349/full/v7/i3/361.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i3.361

Full Article (PDF)	WJGPT-7-361.pdf
Full Article (Word)	WJGPT-7-361.doc
Manuscript File	26347-Review.docx
Answering Reviewers	26347-Answering reviewers.pdf
Audio Core Tip	26347-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26347-Conflict-of-interest statement.pdf
Copyright License Agreement	26347-Copyright assignment.pdf
Peer-review Report	26347-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26347-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26347-Scientific misconduct check.pdf
Scientific Editor Work List	26347-Scientific editor work list.pdf