Publication Name	World Journal of Gastroenterology
Manuscript ID	26525
Country	Finland

Received	2016-04-14 09:41
Peer-Review Started	2016-04-14 11:51
To Make the First Decision	2016-06-20 09:03
Return for Revision	2016-06-20 15:19
Revised
Second Decision	2016-07-21 10:14
Accepted by Journal Editor-in-Chief	2016-07-21 16:11
Accepted by Company Editor-in-Chief	2016-08-01 14:13
Articles in Press	2016-08-01 14:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-19 11:53
Publish the Manuscript Online	2016-12-26 19:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Irritable bowel syndrome symptom severity improves equally with probiotic and placebo
Manuscript Source	Unsolicited Manuscript
All Author List	Anna Lyra, Markku Hillilä, Teppo Huttunen, Sofia Männikkö, Mikko Taalikka, Julia Tennilä, Anneli Tarpila, Sampo Lahtinen, Arthur C Ouwehand and Lea Veijola
Funding Agency and Grant Number
Corresponding Author	Anna Lyra, PhD, Senior Scientist, DuPont Nutrition and Health, Global Health and Nutrition Science, Danisco Sweeteners Oy, Sokeritehtaantie 20, 02460 Kantvik, Finland. anna.lyra@dupont.com
Key Words	Irritable bowel syndrome; Functional bowel disorder; Symptom questionnaire; Quality of life; Visceral pain; Abdominal pain; Lactobacillus acidophilus; Probiotic; Intervention
Core Tip	Symptoms of irritable bowel syndrome (IBS) might benefit from probiotic interventions, although mechanistic insights into probiotic function are seldom available. Lactobacillus acidophilus NCFM induces human colonic mucosal opioid receptor expression - the putative mechanism by which visceral pain is alleviated. In this study, 391 volunteers with IBS were treated with 109 or 1010 colony-forming units of NCFM or placebo and evaluated using symptom questionnaires. NCFM was not superior to placebo in improving the composite IBS symptom score, whereas abdominal pain - as an individual symptom - declined in IBS volunteers with moderate to severe pain at baseline.
Publish Date	2016-12-26 19:13
Citation	Lyra A, Hillilä M, Huttunen T, Männikkö S, Taalikka M, Tennilä J, Tarpila A, Lahtinen S, Ouwehand AC, Veijola L. Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. World J Gastroenterol 2016; 22(48): 10631-10642
URL	http://www.wjgnet.com/1007-9327/full/v22/i48/10631.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i48.10631

Full Article (PDF)	WJG-22-10631.pdf
Full Article (Word)	WJG-22-10631.doc
Manuscript File	26525-Review.docx
Answering Reviewers	26525-Answering reviewers.pdf
Audio Core Tip	26525-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20160413210051.docx
Clinical Trial Registration Statement	26525-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	26525-Conflict-of-interest statement.pdf
Copyright License Agreement	26525-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	Grant_Application_Form_20160413205115.pdf
Signed Informed Consent Form(s) or Document(s)	26525-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20160413210334.docx
Institutional Review Board Approval Form or Document	26525-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	26525-Language certificate.pdf
Peer-review Report	26525-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26525-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26525-Scientific misconduct check.pdf
Scientific Editor Work List	26525-Scientific editor work list.pdf