Publication Name	World Journal of Transplantation
Manuscript ID	26566
Country	United States

Received	2016-04-16 11:04
Peer-Review Started	2016-04-19 09:57
First Decision by Editorial Office Director
Return for Revision	2016-06-14 10:07
Revised	2016-07-02 05:52
Publication Fee Transferred
Second Decision by Editor	2016-09-02 10:56
Second Decision by Editor-in-Chief	2016-09-05 15:29
Final Decision by Editorial Office Director	2016-09-18 14:46
Articles in Press	2016-09-18 14:46
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-05 14:27
Publish the Manuscript Online	2016-12-14 14:32

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	Biology of chronic graft-vs-host disease: Immune mechanisms and progress in biomarker discovery
Manuscript Source	Invited Manuscript
All Author List	Richard B Presland
Funding Agency and Grant Number
Corresponding Author	Richard B Presland, PhD, Department of Oral Health Sciences, School of Dentistry, University of Washington, 1959 NE Pacific St, Box 357475, Seattle, WA 98195, United States. rp@uw.edu
Key Words	Chronic graft-vs-host disease; Biomarker; Allogeneic hematopoietic stem cell transplantation; Cytokine
Core Tip	Chronic graft-vs-host disease (cGVHD) is a frequent long-term medical complication of allogeneic hematopoietic stem cell transplantation which can have a devastating impact on overall health and quality of life. This immune-mediated disorder manifests as an inflammatory and autoimmune-like disorder that can affect multiple tissues in an individual patient. Both clinical and animal studies demonstrate that multiple T cell subsets, as well as B cells, and their secreted cytokines play important roles in cGVHD initiation and progression. In the last decade many molecular biomarkers have been identified that correlate with cGVHD onset and/or progression, and some might have applications clinically in the near future.
Publish Date	2016-12-14 14:32
Citation	Presland RB. Biology of chronic graft-vs-host disease: Immune mechanisms and progress in biomarker discovery. World J Transplant 2016; 6(4): 608-619
URL	http://www.wjgnet.com/2220-3230/full/v6/i4/608.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i4.608

Full Article (PDF)	WJT-6-608.pdf
Full Article (Word)	WJT-6-608.doc
Manuscript File	26566-Review.docx
Answering Reviewers	26566-Answering reviewers.pdf
Audio Core Tip	26566-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26566-Conflict-of-interest statement.pdf
Copyright License Agreement	26566-Copyright assignment.pdf
Peer-review Report	26566-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26566-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26566-Scientific misconduct check.pdf
Scientific Editor Work List	26566-Scientific editor work list.pdf