Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26593
Country	United States

Received	2016-04-18 09:34
Peer-Review Started	2016-04-18 17:31
To Make the First Decision	2016-05-17 12:19
Return for Revision	2016-05-18 11:38
Revised	2016-05-27 10:45
Second Decision	2016-06-13 16:59
Accepted by Journal Editor-in-Chief	2016-06-14 10:18
Accepted by Executive Editor-in-Chief	2016-06-29 10:02
Articles in Press	2016-06-29 10:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-20 09:03
Publish the Manuscript Online	2016-08-01 11:49

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Clinical significance and management of Barrett’s esophagus with epithelial changes indefinite for dysplasia
Manuscript Source	Invited Manuscript
All Author List	Prashanthi N Thota, Gaurav Kistangari, Ashwini K Esnakula, David Hernandez Gonzalo and Xiu-Li Liu
Funding Agency and Grant Number
Corresponding Author	Xiu-Li Liu, MD, PhD, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, United States. xiuliliu@ufl.edu
Key Words	Barrett’s esophagus; Dysplasia; Progression; Biomarkers; Esophageal adenocarcinoma; Indefinite for dysplasia
Core Tip	Barrett’s esophagus (BE) with indefinite for dysplasia (IND) is diagnosed when the epithelial abnor?malities are not sufficient to diagnose dysplasia or the nature of the epithelial abnormalities is uncertain due to inflammation. The risk of prevalent neoplasia in BE with IND varies between 1.9% and 15%. The progression to advanced neoplasia reported varies from 0.43 to 1.2 cases per 100 person-years at risk. Predictors such as the length of BE segment, multi-focality of BE IND, age > 60 years, abnormal p53 expression, active inflammation, and abnormal DNA content as detected by flow cytometry may help in risk-stratifying this patient population.
Publish Date	2016-08-01 11:49
Citation	Thota PN, Kistangari G, Esnakula AK, Gonzalo DH, Liu XL. Clinical significance and management of Barrett’s esophagus with epithelial changes indefinite for dysplasia. World J Gastrointest Pharmacol Ther 2016; 7(3): 406-411
URL	http://www.wjgnet.com/2150-5349/full/v7/i3/406.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i3.406

Full Article (PDF)	WJGPT-7-406.pdf
Full Article (Word)	WJGPT-7-406.doc
Manuscript File	26593-Review.docx
Answering Reviewers	26593-Answering reviewers.pdf
Audio Core Tip	26593-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26593-Conflict-of-interest statement.pdf
Copyright License Agreement	26593-Copyright assignment.pdf
Peer-review Report	26593-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26593-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26593-Scientific misconduct check.pdf
Scientific Editor Work List	26593-Scientific editor work list.pdf