Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	26650
Country	Canada

Received	2016-04-20 12:14
Peer-Review Started	2016-04-20 16:59
First Decision by Editorial Office Director
Return for Revision	2016-06-12 15:38
Revised	2016-07-15 01:36
Publication Fee Transferred
Second Decision by Editor	2016-08-30 11:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-09-08 17:02
Articles in Press	2016-09-08 17:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-02 17:40
Publish the Manuscript Online	2016-12-14 09:26

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience
Manuscript Source	Unsolicited Manuscript
All Author List	Alexandra Shingina, George Ou, Oliver Takach, Sigrid Svarta, Ricky Kwok, Jessica Tong, Kieran Donaldson, Eric Lam and Robert Enns
Funding Agency and Grant Number
Corresponding Author	Robert Enns, MD, Division of Gastroen­terology, Saint Paul Hospital, 770-1190 Hornby Street, Vancouver V6Z 2K5, Canada. rob.enns@ubc.ca
Key Words	Colonoscopy; Sedation; Sedation tolerance; Fentanyl; Midazolam; Predictive model
Core Tip	This manuscript explores patient specific characteristics that are associated with increased sedation tolerance based on retrospective review of 5000 patients that underwent outpatient colonoscopies. Using a logistic regression analysis, we developed a predictive model that can identify patients requiring higher than usual sedation doses using pre-procedurally available patient parameters. The final prediction model that includes age, indication for the procedure, medication/substance use, previous surgeries yielded an area under the curve of 0.76 for Fentanyl ≥ 100 mcg and Midazolam ≥ 3 mg. This modelling could help optimize periprocedural planning and potentially identify patients who would benefit from alternative sedation methods, e.g., propofol.
Publish Date	2016-12-14 09:26
Citation	Shingina A, Ou G, Takach O, Svarta S, Kwok R, Tong J, Donaldson K, Lam E, Enns R. Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience. World J Gastrointest Endosc 2016; 8(20): 770-776
URL	http://www.wjgnet.com/1948-5190/full/v8/i20/770.htm
DOI	http://dx.doi.org/10.4253/wjge.v8.i20.770

Full Article (PDF)	WJGE-8-770.pdf
Full Article (Word)	WJGE-8-770.doc